Novel aspects of signal processing in lamina I

Abstract

The most superficial layer of the spinal dorsal horn, lamina I, is a key element of the nociceptive processing system. It contains different types of projection neurons (PNs) and local-circuit neurons (LCNs) whose functional roles in the signal processing are poorly understood. This article reviews recent progress in elucidating novel anatomical features and physiological properties of lamina I PNs and LCNs revealed by whole-cell recordings in ex vivo spinal cord. This article is part of the Special Issue on "Ukrainian Neuroscience".

Keywords: Interneurons; Marginal zone; Migraine; Mirror pain; Nociception; Presynaptic inhibition; Referred pain; Rhythmic firing; Trigeminocervical complex.