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. 1987 Feb 10;403(1):142-6.
doi: 10.1016/0006-8993(87)90133-8.

Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs?

J P Rivot, B Calvino, J M Besson

Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs?

J P Rivot et al. Brain Res. .

Abstract

In the anaesthetized rat the intravenous injection of 5-HT antagonists, cinanserin and methysergide, induces in two-thirds of neurones studied, an increase in the responsiveness of dorsal horn convergent neurones to C-fibre stimulation. These results are in favour of the existence of serotonergic tonic descending inhibitory effects on the spinal transmission of noxious messages.

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