Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 15:10:1306276.
doi: 10.3389/fmed.2023.1306276. eCollection 2023.

The relationships between lens diameter and ocular biometric parameters: an ultrasound biomicroscopy-based study

Zhiqian Huang  1   2   3   4   5 , Jiao Qi  1   2   3   4   5 , Kaiwen Cheng  1   2   3   4   5 , Shuyu Liu  1   2   3   4   5 , Keke Zhang  1   2   3   4   5 , Yu Du  1   2   3   4   5 , Yi Lu  1   2   3   4   5 , Xiangjia Zhu  1   2   3   4   5
Affiliations

The relationships between lens diameter and ocular biometric parameters: an ultrasound biomicroscopy-based study

Zhiqian Huang et al. Front Med (Lausanne). .

Abstract

Purpose: This study aims to explore the relationships between lens diameter (LD) measured with ultrasound biomicroscopy (UBM) and ocular biometric parameters.

Methods: Ocular biometric parameters including axial length (AL), white-to-white distance (WTW), anterior chamber depth (ACD), lens thickness (LT) and anterior segment length (ASL) were measured with IOL-Master 700, and the direct measurement of LD was conducted through UBM (ArcScan Insight 100). Relationships between LD and ocular biometric parameters were then investigated. Eyes with AL ≥ 28 mm were defined as eyes with extreme myopia, and eyes with AL < 28 mm were defined as eyes without extreme myopia.

Results: A total of 194 eyes from 194 subjects were included. The mean LD was 9.58 ± 0.49 mm, ranging from 8.60 to 10.96 mm. According to univariate analysis, larger LD was associated with elder age, male gender, larger WTW, ACD and ASL (all p < 0.05). Meanwhile, the LD was positively correlated with AL in eyes without extreme myopia (p < 0.05), but not in eyes with extreme myopia (p > 0.05). Backward stepwise regressions revealed that a larger LD was associated with larger WTW, ASL and AL in eyes without extreme myopia (all p < 0.05), while ASL was the only significant variable in eyes with extreme myopia (p < 0.05).

Conclusion: Larger WTW, ASL and AL in eyes without extreme myopia, as well as longer ASL in eyes with extreme myopia indicated a larger LD, which provides guidance in personalized surgical choice and promises ideal visual outcomes.

Keywords: anterior segment length; axial length; lens diameter; ultrasound biomicroscopy; white-to-white distance.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Lens imaging and measurement of lens diameter with ArcScan Insight 100. (A) Original image. (B) Two best fitting arcs (in blue) were generated to delineate the equator of the lens, then the lens diameter (LD) was measured as the distance between the vertex of the circular arcs on both sides of the lens (in yellow). (C) Two auxiliary lines (in red) were introduced at the intersection of our fitting arc and the observed anterior or posterior curve to ensure the alignment, with the perpendicular angle defining the fitting arc (in blue) as the best fit.
Figure 2
Figure 2
Distribution of lens diameter (LD) among this study population.
Figure 3
Figure 3
Associations of lens diameter (LD) with age, sex and ocular biometric parameters. (A) LD was positively correlated with age (r = 0.206, p = 0.004). (B) The LD of males was significantly larger than that of females (** p < 0.01). Correlations between lens diameter (LD) and (C) white-to-white distance (WTW) (r = 0.288, p < 0.001), (D) anterior chamber depth (ACD) (r = 0.331, p < 0.001), (E) lens thickness (LT) (r = 0.074, p = 0.301), (F) anterior segment length (ASL) (r = 0.448, p < 0.001).
Figure 4
Figure 4
Changes of lens diameter (LD) with axial length (AL). (A) Compared with the AL 22–24.5 mm group, the AL < 22 mm group had significantly smaller LDs and the AL 26–28 mm group had significantly larger LDs (** p < 0.01). With the increase of AL, the LD was firstly increased gradually to peak in the AL 26–28 mm group, then decreased slightly. (B) The correlation between LD and AL was significantly positive in eyes without extreme myopia (r = 0.398, p < 0.001), but not significant in eyes with extreme myopia (r = 0.175, p = 0.323).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, et al. . Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis. Eye (Lond). (2020) 34:1357–70. doi: 10.1038/s41433-020-0806-3 - DOI - PMC - PubMed
    1. Meng J, He W, Rong X, Miao A, Lu Y, Zhu X. Decentration and tilt of plate-haptic multifocal intraocular lenses in myopic eyes. Eye Vis (Lond). (2020) 7:17. doi: 10.1186/s40662-020-00186-3, PMID: - DOI - PMC - PubMed
    1. Chen X, Gu X, Wang W, Xiao W, Jin G, Wang L, et al. . Characteristics and factors associated with intraocular lens tilt and decentration after cataract surgery. J Cataract Refract Surg. (2020) 46:1126–31. doi: 10.1097/j.jcrs.0000000000000219, PMID: - DOI - PubMed
    1. Yao Y, Lu Q, Wei L, Cheng K, Lu Y, Zhu X. Efficacy and complications of cataract surgery in high myopia. J Cataract Refract Surg. (2021) 47:1473–80. doi: 10.1097/j.jcrs.0000000000000664 - DOI - PubMed
    1. Zhu X, He W, Zhang Y, Chen M, Du Y, Lu Y. Inferior Decentration of multifocal intraocular lenses in myopic eyes. Am J Ophthalmol. (2018) 188:1–8. doi: 10.1016/j.ajo.2018.01.007, PMID: - DOI - PubMed