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Review
. 2024 Mar;102(3):337-351.
doi: 10.1007/s00109-024-02417-9. Epub 2024 Jan 30.

Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules

Yue Zhao  1   2 , Jiaojiao Huang  2 , Kexin Zhao  2 , Min Li  2 , Shengjun Wang  3   4
Affiliations
Review

Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules

Yue Zhao et al. J Mol Med (Berl). 2024 Mar.

Abstract

N6 methyladenosine (m6A) is the most prevalent RNA epigenetic modification, regulated by methyltransferases and demethyltransferases and recognized by methylation-related reading proteins to impact mRNA splicing, translocation, stability, and translation efficiency. It significantly affects a variety of activities, including stem cell maintenance and differentiation, tumor formation, immune regulation, and metabolic disorders. Ubiquitination refers to the specific modification of target proteins by ubiquitin molecule in response to a series of enzymes. E3 ligases connect ubiquitin to target proteins and usually lead to protein degradation. On the contrary, deubiquitination induced by deubiquitinating enzymes (DUBs) can separate ubiquitin and regulate the stability of protein. Recent studies have emphasized the potential importance of ubiquitination and deubiquitination in controlling the function of m6A modification. In this review, we discuss the impact of ubiquitination and deubiquitination on m6A functional molecules in diseases, such as metabolism, cellular stress, and tumor growth.

Keywords: Degradation; Deubiquitination; RNA modification; Ubiquitination; m6A.

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References

    1. Bokar JA et al (1994) Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. J Biol Chem 269(26):17697–17704 - PubMed - DOI
    1. Li M et al (2021) The role of N6-methyladenosine mRNA in the tumor microenvironment. Biochim Biophys Acta Rev Cancer 1875(2):188522 - PubMed - DOI
    1. Yang Y et al (2018) Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res 28(6):616–624 - PubMed - PMC - DOI
    1. Meyer KD et al (2012) Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149(7):1635–1646 - PubMed - PMC - DOI
    1. Dominissini D et al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485(7397):201–206 - PubMed - DOI

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