Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Oct 1;61(266):828-830.
doi: 10.31729/jnma.8298.

Systemic Sclerosis with Inflammatory Myositis: A Case Report

Suju Bhattarai  1 , Jyoti Pudasaini  1 , Ashutosh Sharma  1 , Manjil Bharati  1 , Narayan Dhakal  2
Affiliations
Case Reports

Systemic Sclerosis with Inflammatory Myositis: A Case Report

Suju Bhattarai et al. JNMA J Nepal Med Assoc. .

Abstract

The overlap of systemic sclerosis and inflammatory myositis is a rare disorder which results in immune system activation and production of autoantibodies. We present a case of a 28-year-old female with complaints of generalized weakness, multiple joint pain, facial puffiness, and blackish discolouration of skin over the last 4 months. Blood investigations demonstrated autoantibodies positive for overlap syndrome. She was managed with hydroxychloroquine, mycophenolate mofetil and steroids. This case report highlights the importance of early diagnosis and treatment of this rare entity for better patient outcomes.

Keywords: antibodies; case reports; inflammation; systemic sclerosis.

PubMed Disclaimer

Conflict of interest statement

None.

References

    1. Furue M, Mitoma C, Mitoma H, Tsuji G, Chiba T, Nakahara T, et al. Pathogenesis of systemic sclerosis-current concept and emerging treatments. Immunol Res. 2017 Aug;65(4):790–7. doi: 10.1007/s12026-017-8926-y. - DOI - PubMed
    1. Bairkdar M, Rossides M, Westerlind H, Hesselstrand R, Arkema EV, Holmqvist M. Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis. Rheumatology (Oxford). 2021 Jul 1;60(7):3121–33. doi: 10.1093/rheumatology/keab190. - DOI - PMC - PubMed
    1. Dobloug GC, Svensson J, Lundberg IE, Holmqvist M. Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study. Ann Rheum Dis. 2018 Jan;77(1):40–7. doi: 10.1136/annrheumdis-2017-211402. - DOI - PubMed
    1. Pokeerbux MR, Giovannelli J, Dauchet L, Mouthon L, Agard C, Lega JC, et al. Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature. Arthritis Res Ther. 2019 Apr 3;21(1):86. doi: 10.1186/s13075-019-1867-1. - DOI - PMC - PubMed
    1. Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA. Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med. 2000 Jan;124(1):71–81. doi: 10.5858/2000-124-0071-GFCUOT. - DOI - PubMed

Publication types

LinkOut - more resources