Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

He-Ling Wang¹, Richard Siow², Tomas Schmauck-Medina¹, Jianying Zhang^{1

3}, Per Morten Sandset^{4

5}, Clare Filshie⁶, Øystein Lund⁷, Linda Partridge^{8

9}, Linda Hildegard Bergersen^{10

11}, Lene Juel Rasmussen¹², Konstantinos Palikaras¹³, Ioannis Sotiropoulos^{14

15}, Jon Storm-Mathisen¹⁶, David C Rubinsztein^{17

18}, Maria Grazia Spillantini¹⁹, Chris I De Zeeuw^{20

21}, Leiv Otto Watne²², Martin Vyhnalek^{23

24}, Katerina Veverova²⁴, Kristina Xiao Liang²⁵, Nektarios Tavernarakis^{26

27}, Vilhelm A Bohr^{12

28}, Koutaro Yokote²⁹, Janna Saarela^{30

31}, Hilde Nilsen^{32

33}, Efstathios S Gonos³⁴, Morten Scheibye-Knudsen^{12

35}, Guobing Chen^{36

37}, Hisaya Kato²⁹, Geir Selbæk^{5

38}, Tormod Fladby^{22

39}, Per Nilsson⁴⁰, Anne Simonsen^{41

42}, Dag Aarsland^{43

44}, Sofie Lautrup¹, Ole Petter Ottersen^{45

46}, Lynne S Cox⁴⁷, Evandro F Fang^{1

33}

Affiliations

¹ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
² School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
³ Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
⁴ Department of Haematology, Oslo University Hospital, Oslo, Norway.
⁵ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁶ British Embassy Oslo, Oslo, Norway.
⁷ Royal Norwegian Embassy in London, London, UK.
⁸ Max Planck Institute for Biology of Ageing, Cologne, Germany.
⁹ Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London (UCL), London, UK.
¹⁰ Brain and Muscle Energy Group, Institute of Oral Biology, University of Oslo, Oslo, Norway.
¹¹ Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
¹² Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
¹³ Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
¹⁴ Institute of Biosciences and Applications NCSR "Demokritos," Athens, Greece.
¹⁵ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, Braga, Portugal.
¹⁶ Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
¹⁷ Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
¹⁸ UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
¹⁹ Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
²⁰ Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
²¹ Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
²² Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
²³ International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic.
²⁴ Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
²⁵ Department of Clinical Medicine, University of Bergen, Bergen, Norway.
²⁶ Institute of Molecular Biology and Biotechnology Foundation for Research and Technology, Heraklion, Greece.
²⁷ Medical School, University of Crete, Heraklion, Greece.
²⁸ Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
²⁹ Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
³⁰ Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway.
³¹ Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
³² Department of Microbiology, Oslo University Hospital, Oslo, Norway.
³³ The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
³⁴ National Helenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
³⁵ Tracked.bio, Copenhagen, Denmark.
³⁶ Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China.
³⁷ Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
³⁸ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
³⁹ Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
⁴⁰ Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
⁴¹ Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁴² Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital Montebello, Oslo, Norway.
⁴³ Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
⁴⁴ Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
⁴⁵ Centre for Sustainable Healthcare Education, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁴⁶ Karolinska Institutet, Stockholm, Sweden.
⁴⁷ Department of Biochemistry, University of Oxford, Oxford, UK.

PMID: 38289789
PMCID: PMC10917444
DOI: 10.1093/gerona/glae029

Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

He-Ling Wang et al. J Gerontol A Biol Sci Med Sci. 2024.

. 2024 Apr 1;79(4):glae029.

doi: 10.1093/gerona/glae029.

Authors

Affiliations

¹ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
² School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
³ Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
⁴ Department of Haematology, Oslo University Hospital, Oslo, Norway.
⁵ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁶ British Embassy Oslo, Oslo, Norway.
⁷ Royal Norwegian Embassy in London, London, UK.
⁸ Max Planck Institute for Biology of Ageing, Cologne, Germany.
⁹ Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London (UCL), London, UK.
¹⁰ Brain and Muscle Energy Group, Institute of Oral Biology, University of Oslo, Oslo, Norway.
¹¹ Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
¹² Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
¹³ Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
¹⁴ Institute of Biosciences and Applications NCSR "Demokritos," Athens, Greece.
¹⁵ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, Braga, Portugal.
¹⁶ Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
¹⁷ Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
¹⁸ UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
¹⁹ Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
²⁰ Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
²¹ Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
²² Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
²³ International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic.
²⁴ Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
²⁵ Department of Clinical Medicine, University of Bergen, Bergen, Norway.
²⁶ Institute of Molecular Biology and Biotechnology Foundation for Research and Technology, Heraklion, Greece.
²⁷ Medical School, University of Crete, Heraklion, Greece.
²⁸ Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
²⁹ Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
³⁰ Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway.
³¹ Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
³² Department of Microbiology, Oslo University Hospital, Oslo, Norway.
³³ The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
³⁴ National Helenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
³⁵ Tracked.bio, Copenhagen, Denmark.
³⁶ Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China.
³⁷ Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
³⁸ Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
³⁹ Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
⁴⁰ Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
⁴¹ Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁴² Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital Montebello, Oslo, Norway.
⁴³ Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
⁴⁴ Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
⁴⁵ Centre for Sustainable Healthcare Education, Faculty of Medicine, University of Oslo, Oslo, Norway.
⁴⁶ Karolinska Institutet, Stockholm, Sweden.
⁴⁷ Department of Biochemistry, University of Oxford, Oxford, UK.

PMID: 38289789
PMCID: PMC10917444
DOI: 10.1093/gerona/glae029

Abstract

Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such as dementia, and promoting healthy longevity in the old population. In response to the challenge of the aging population and with a view to the future, Norway and the United Kingdom are fostering collaborations, supported by a "Money Follows Cooperation agreement" between the 2 nations. The inaugural Norway-UK joint meeting on aging and dementia gathered leading experts on aging and dementia from the 2 nations to share their latest discoveries in related fields. Since aging is an international challenge, and to foster collaborations, we also invited leading scholars from 11 additional countries to join this event. This report provides a summary of the conference, highlighting recent progress on molecular aging mechanisms, genetic risk factors, DNA damage and repair, mitophagy, autophagy, as well as progress on a series of clinical trials (eg, using NAD+ precursors). The meeting facilitated dialogue among policymakers, administrative leaders, researchers, and clinical experts, aiming to promote international research collaborations and to translate findings into clinical applications and interventions to advance healthy aging.

Keywords: Aging; Alzheimer’s disease; Dementia; Longevity; Neurodegeneration.

PubMed Disclaimer

Conflict of interest statement

E.F.F. is the co-owner of Fang-S Consultation AS (Organization number 931 410 717); he has an MTA with LMITO Therapeutics Inc. (South Korea), a CRADA arrangement with ChromaDex (USA), and a commercialization agreement with Molecule AG/VITADAO; he is a consultant to Aladdin Healthcare Technologies (United Kingdom and Germany), the Vancouver Dementia Prevention Centre (Canada), Intellectual Labs (Norway), MindRank AI (China), and NYO3 (Norway and China). L.S.C. is co-director of the UK Ageing research networks (UKANet.org.uk) and program director of the Dynamic Resilience program, jointly funded by Wellcome Leap and Temasek Trust. The other authors declare no conflict.

Figures

**Figure 1.**
Group photo of The NYO3 5th NO-Age/AD meeting and the 1st Norway–UK joint meeting on aging and dementia.

See this image and copyright information in PMC

References

1. WHO. Ageing and Health; 2022.
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1. Fang EF, Scheibye-Knudsen M, Jahn HJ, et al. . A research agenda for aging in China in the 21st century. Ageing Res Rev. 2015;24:197–205. 10.1016/j.arr.2015.08.003 - DOI - PMC - PubMed
1. Woods T, Palmarini N, Corner L, et al. . Quantum healthy longevity for healthy people, planet, and growth. Lancet Healthy Longev. 2022;3:e811–e813. 10.1016/S2666-7568(22)00267-7 - DOI - PubMed
1. Livingston G, Huntley J, Sommerlad A, et al. . Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396:413–446. 10.1016/S0140-6736(20)30367-6 - DOI - PMC - PubMed

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Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

Affiliations

Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Medical