PECULIARITIES OF PULMONARY VENTILATION RESPONSE TO DOSED HYPOXIA IN ELDERLY PEOPLE WITH IMPAIRED GLUCOSE TOLERANCE

Abstract

Objective: The aim: To determine the peculiarities of the response of pulmonary ventilation to hypoxia in elderly people with impaired glucose tolerance.

Patients and methods: Materials and methods: Forty-three elderly people were examined, including 20 patients with impaired glucose tolerance and 23 healthy individuals with preserved glucose tolerance. Fasting plasma glucose and insulin concentrations were determined, and the HOMA-IR insulin resistance index was calculated. Under conditions of normoxia and during a dosed hypoxic test (12% oxygen, duration 20 min), blood saturation and lung ventilation parameters were monitored.

Results: Results: Under conditions of normoxia, the indicators of lung ventilation function did not differ between the groups of elderly people with impaired and preserved glucose tolerance. Under conditions of hypoxia, elderly people with impaired glucose tolerance had a less significant increase in ventilation, despite the development of more severe arterial hypoxemia. This leads to a decrease in the ventilatory response to hypoxia in case of impaired carbohydrate metabolism.

Conclusion: Conclusions: In people with impaired glucose tolerance, a less significant ventilatory response to hypoxia is combined with more pronounced insulin resistance.

Keywords: aging; hypoxia; impaired glucose tolerance; insulin resistance; ventilation.