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Editorial
. 2024 May 3;26(5):840-842.
doi: 10.1093/neuonc/noae019.

TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion?

Sourav Ghosh  1 , Carla V Rothlin  2
Affiliations
Editorial

TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion?

Sourav Ghosh et al. Neuro Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Comment on

  • TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas.
    Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Bosco DB, Huang T, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Qi F, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ. Zheng J, et al. Neuro Oncol. 2024 May 3;26(5):811-825. doi: 10.1093/neuonc/noad214. Neuro Oncol. 2024. PMID: 37941134 Free PMC article.
  • Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma.
    Peshoff MM, Gupta P, Oberai S, Trivedi R, Katayama H, Chakrapani P, Dang M, Migliozzi S, Gumin J, Kadri DB, Lin JK, Milam NK, Maynard ME, Vaillant BD, Parker-Kerrigan B, Lang FF, Huse JT, Iavarone A, Wang L, Clise-Dwyer K, Bhat KP. Peshoff MM, et al. Neuro Oncol. 2024 May 3;26(5):826-839. doi: 10.1093/neuonc/noad257. Neuro Oncol. 2024. PMID: 38237157 Free PMC article.

References

    1. Sun R, Han R, McCornack C, et al.. TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Sci Adv. 2023;9(19):eade3559. - PMC - PubMed
    1. Zheng J, et al.. TREM2 mediates MHCII-associated CD4+ T cell response against gliomas. Neuro Oncol. 2024;26(5):811–825. - PMC - PubMed
    1. Peshoff MM, Gupta P, Oberai S, et al.. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. Neuro Oncol. 2024;26(5):826–839. - PMC - PubMed
    1. Qin T, Mullan B, Ravindran R, et al.. ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization. Cell Rep. 2022;38(2):110216. - PMC - PubMed
    1. Kosaka A, Ohkuri T, Okada H.. Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. Cancer Immunol Immunother. 2014;63(8):847–857. - PMC - PubMed

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