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. 2024 Apr;99(4):755-758.
doi: 10.1002/ajh.27203. Epub 2024 Jan 30.

The prognostic impact of non-driver gene mutations and variant allele frequency in primary myelofibrosis

Alberto Hernández-Sánchez  1   2 , Ángela Villaverde-Ramiro  2 , Eduardo Arellano-Rodrigo  3 , Marta Garrote  3 , Iván Martín  4 , Adrián Mosquera-Orgueira  5 , María-Teresa Gómez-Casares  6 , Francisca Ferrer-Marín  7 , Esperanza Such  8 , Patricia Velez  9 , Rosa Ayala  10 , Anna Angona  11 , Natalia de Las Heras  12 , Elena Magro  13 , María-Isabel Mata-Vázquez  14 , María-Laura Fox  15 , Sonia González de Villambrosía  16 , María-José Ramírez  17 , Ana García  18 , Valentín García-Gutiérrez  19 , Amparo Cáceres  20 , María-Antonia Durán  21 , Alicia Senín  22 , José-María Raya  23 , José Antonio González  24 , Beatriz Cuevas  25 , Blanca Xicoy  26 , Manuel Pérez-Encinas  5 , Beatriz Bellosillo  9 , Alberto Álvarez-Larrán  3 , Jesús María Hernández-Rivas  1   2 , Juan Carlos Hernández-Boluda  4 ; Spanish MPN Group (GEMFIN)
Affiliations
Free article

The prognostic impact of non-driver gene mutations and variant allele frequency in primary myelofibrosis

Alberto Hernández-Sánchez et al. Am J Hematol. 2024 Apr.
Free article

Abstract

Prognostic impact of non-MPN driver gene mutations in primary myelofibrosis. MIPSS70: Mutation-Enhanced International Prognostic Score System.

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References

REFERENCES

    1. Guglielmelli P, Lasho TL, Rotunno G, et al. MIPSS70: mutation-enhanced international prognostic score system for transplantation-age patients with primary myelofibrosis. J Clin Oncol. 2018;36(4):310-318.
    1. Tefferi A, Guglielmelli P, Lasho TL, et al. MIPSS70+ version 2.0: mutation and karyotype-enhanced international prognostic scoring system for primary myelofibrosis. J Clin Oncol. 2018;36(17):1769-1770.
    1. Paz DL, Riou J, Verger E, et al. Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study. Blood Adv. 2021;5(5):1442-1451.
    1. Guglielmelli P, Coltro G, Mannelli F, et al. ASXL1 mutations are prognostically significant in PMF, but not MF following essential thrombocythemia or polycythemia vera. Blood Adv. 2022;6(9):2927-2931.
    1. Loscocco GG, Rotunno G, Mannelli F, et al. The prognostic contribution of CBL, NRAS, KRAS, RUNX1, and TP53 mutations to mutation-enhanced international prognostic score systems (MIPSS70/plus/plus v2.0) for primary myelofibrosis. Am J Hematol. 2024;99(1):68-78.

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