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Multicenter Study
. 2024 Mar;29(1):72-81.
doi: 10.1111/jns.12612. Epub 2024 Jan 30.

Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study

Volkan Tasdemir  1 , Nermin Gorkem Sirin  1 , Arman Cakar  1 , Ayla Culha  2 , Aysun Soysal  3 , Ayse Deniz Elmali  1 , Aysegul Gunduz  4 , Beyza Arslan  5 , Destina Yalcin  6 , Dilek Atakli  3 , Elif Kocasoy Orhan  1 , Elif Sanli  7 , Erdem Tuzun  7 , Eren Gozke  8 , Esra Gursoy  9 , Feray Karaali Savrun  4 , Ferda Ilgen Uslu  9 , Fikret Aysal  10 , Hacer Durmus  1 , Hafsa Bulbul  5 , F Inci Ertas  11 , Kayihan Uluc  5 , Kemal Tutkavul  12 , Leyla Baysal  13 , Mehmet Baris Baslo  1 , Meral Kiziltan  4 , Metin Mercan  14 , Nevin Pazarci  6 , Nurten Uzun  4 , Onur Akan  13 , Ozlem Cokar  2 , Pinar Kahraman Koytak  5 , Reyhan Sürmeli  6 , Sefer Gunaydin  2 , Selahattin Ayas  4 , Sezin Alpaydin Baslo  3 , Vildan Yayla  14 , Vuslat Yilmaz  7 , Yesim Parman  1 , Zeliha Matur  9 , Zeynep Unlusoy Acar  2 , Ali Emre Oge  1
Affiliations
Multicenter Study

Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study

Volkan Tasdemir et al. J Peripher Nerv Syst. 2024 Mar.

Abstract

Background and aims: This study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain-Barré syndrome (GBS) in Istanbul.

Methods: Patients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti-ganglioside antibodies were analyzed.

Results: One hundred seventy-seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019-February 2020) and 108 during the pandemic (March 2020-March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.'s criteria (76/174, 43.7%). Fourteen patients' diagnoses made using Rajabally et al.'s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti-ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies.

Interpretation: Serial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis.

Keywords: Guillain-Barré syndrome; anti-ganglioside antibodies; diagnostic criteria; electrodiagnosis; serial examinations.

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References

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