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Review
. 2024 Jul;56(3):700-720.
doi: 10.4143/crt.2023.1138. Epub 2024 Jan 30.

HER2-Low Breast Cancer: Now and in the Future

Sora Kang  1 , Sung-Bae Kim  2
Affiliations
Review

HER2-Low Breast Cancer: Now and in the Future

Sora Kang et al. Cancer Res Treat. 2024 Jul.

Abstract

Breast cancer is a heterogeneous disease, and its subtypes are characterized by hormone receptor and human epidermal growth factor receptor 2 (HER2) expression status. "HER2-low" tumors, which exhibit a low level of HER2 expression (immunohistochemistry 1+ or 2+ without gene amplification), were conventionally considered not amenable to anti-HER2 targeting agents based on the results of a phase III trial of trastuzumab. However, this perspective is being challenged by the emergence of novel anti-HER2 antibody-drug conjugates, such as trastuzumab-deruxtecan. These innovative therapies have demonstrated remarkable efficacy against HER2-low breast cancer, shedding new light on a previously overlooked category of breast cancer. Such promising results highlight the need for in-depth investigations of the biology and prognostic implications of HER2-low tumors. In this review, we comprehensively summarize the current evidence surrounding this topic and highlight areas that warrant further exploration and research in the future.

Keywords: Breast neoplasms; DS-8201a; HER2-low.

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Conflict of interest statement

Conflicts of Interest

Conflict of interest relevant to this article was not reported.

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