Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Mar;51(3):353-364.
doi: 10.1111/1346-8138.17126. Epub 2024 Jan 31.

Cutaneous malignancies in chronic lymphocytic leukemia

Catherine Zilberg  1   2 , Angela L Ferguson  3 , James G Lyons  1   3 , Ruta Gupta  4 , Stephen J Fuller  5   6 , Diona L Damian  1   2
Affiliations
Review

Cutaneous malignancies in chronic lymphocytic leukemia

Catherine Zilberg et al. J Dermatol. 2024 Mar.

Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that is associated with an increased risk of developing cutaneous malignancies. Clinical outcomes for these malignancies, including melanoma and keratinocyte cancers (KC), are worse for patients with CLL. Individuals with CLL develop an immunodeficiency of both the adaptive and innate immune system, which plays a role in the increased prevalence of skin cancers. This review focuses on the complex interplay between genetics, immunity, and pathogens that influence the cellular composition and biology of skin tumors and their microenvironment in CLL patients, and in comparison with other chronic hematological malignancies. It is paramount for dermatologists to be aware of the association between CLL (and chronic hematological malignancies more broadly) and cutaneous malignancies. This is a high-risk population who require regular and vigorous dermatologic follow-up.

Keywords: chronic B-cell; leukemia; melanoma; skin neoplasms; squamous cell.

PubMed Disclaimer

References

REFERENCES

    1. Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, et al. Chronic lymphocytic leukaemia. Nat Rev Dis Primers. 2017;3:16096.
    1. Voisinne G, Gonzalez de Peredo A, Roncagalli R. CD5, an undercover regulator of TCR signaling. Front Immunol. 2018;9:2900.
    1. Naeim F, Nagesh Rao P, Song SX, Phan RT. Chapter 2 - principles of Immunophenotyping. In: Naeim F, Nagesh Rao P, Song SX, Phan RT, editors. (Eds.)Atlas of Hematopathology. 2nd Edition: Academic Press; 2018. p. 29-56.
    1. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
    1. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-1847.

MeSH terms

LinkOut - more resources