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. 2023 Jul 16;11(3):101022.
doi: 10.1016/j.gendis.2023.05.018. eCollection 2024 May.

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

Chen Tan  1   2 , Lingwa Wang  1   2 , Yifan Yang  1   2 , Shizhi He  1   2 , George G Chen  3 , Jason Yk Chan  3 , Michael Cf Tong  3 , C A van Hasselt  3 , Wenbin Xu  4 , Ling Feng  1   2 , Ru Wang  1   2 , Jugao Fang  1   2
Affiliations

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

Chen Tan et al. Genes Dis. .
No abstract available

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Figures

Fig. 1
Figure 1
Construction of a novel six-gene signature to predict tumor response to IC and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma. (A) Study design. (B) Heatmap of 107 selected DEGs, which not only effectively distinguished the tumors from normal tissues, but also distinguished response tumors from non-response tumors. The red and blue points represent up-regulated and down-regulated mRNA expression, respectively. (C) Heat map of the 50 genes that not only distinguished between the response and non-response tumors but also distinguished between the tumor tissues and adjacent normal tissues. Red represents an increase in the mRNA expression and blue represents a decrease in the mRNA expression. (D) ROC analysis of 10 genes predicting tumor response to IC in LA-LHC patients (AUC >80%). (E) Relative expression of six genes validated by qRT-PCR in response and non-response LA-LHC tissues. (F) ROC curve analysis of the six-gene signature and clinical variables for the prediction of short-term tumor response to IC. The 95% confidence interval of AUC and P value were estimated using the bootstrap method. (G) Six genes showed low expression in Cluster 1 and high expression in Cluster 2. Kaplan–Meier analysis showed that overall survival rates were significantly better in Cluster 1 patients than in Cluster 2 patients (P < 0.05).
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References

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