Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Dec 2:44:23-26.
doi: 10.1016/j.jdcr.2023.11.017. eCollection 2024 Feb.

Granulomatous secondary syphilis with pulmonary involvement

Andrew D Johnston  1 , Simon F Roy  1 , Jennifer McNiff  1 , Marco Petrazzuoli  1   2
Affiliations
Case Reports

Granulomatous secondary syphilis with pulmonary involvement

Andrew D Johnston et al. JAAD Case Rep. .
No abstract available

Keywords: HIV; granulomatous syphilis; human immunodeficiency virus; otologic syphilis; pulmonary syphilis; secondary syphilis; secondary syphilis with otologic involvement; secondary syphilis with pulmonary involvement.

PubMed Disclaimer

Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
On the head (A), upper chest (B), and upper portion of the left arm (C), there are representative 5 to 10 mm firm, nontender pink papulonodules without secondary change, which were also noted on the back and legs (not shown). The skin biopsy site is denoted as “H+E” in panel (C). The right palm has 4 ∼5 mm round, thin pink-brown papules with annular scale, consistent with “copper pennies” (D).
Fig 2
Fig 2
A, Hematoxylin and eosin stain demonstrates ill-formed granulomas with lymphocytic and plasma cell inflammation throughout the dermis. B, Immunohistochemistry toward spirochete antigen with background hematoxylin reveals few spindled organisms (brown, denoted by red arrows) within intercellular spaces between keratinocytes in the stratum basale and spinosum.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention . Centers for Disease Control and Prevention; 2021. Neurosyphilis, Ocular Syphilis, and Otosyphilis – STI Treatment Guidelines.
    1. Centers for Disease Control and Prevention . Centers for Disease Control and Prevention; 2021. National Overview of STDs, 2021.
    1. Kidd S., Torrone E., Su J., Weinstock H. Reported Primary and Secondary Syphilis Cases in the United States: implications for HIV infection. Sex Transm Dis. 2018;45(9S Suppl 1):S42–S47. doi: 10.1097/olq.0000000000000810. - DOI - PMC - PubMed
    1. Govender D., Jackson C., Chetty D. Syphilitic pulmonary inflammatory pseudotumor: a diagnostic challenge. Int J Surg Pathol. 2021;29(1):90–96. doi: 10.1177/1066896920928584. - DOI - PubMed
    1. Yang X., Wu W., Wang Y., Wu W., Huang X., Xu L. A case of secondary pulmonary syphilis – the utility of mNGS in bronchoalveolar lavage fluid: a case report. Infect Drug Resist. 2022;15:5215–5219. doi: 10.2147/idr.s373711. - DOI - PMC - PubMed

Publication types

LinkOut - more resources