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. 2024 Jan 15;16(1):110-117.
doi: 10.4251/wjgo.v16.i1.110.

Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors

Chuan-Yu Wang  1 , Xiao-Jing Fan  1 , Fei-Liang Wang  1 , Yue-Yue Ge  1 , Zhao Cai  1 , Wei Wang  2 , Xin-Ping Zhou  3 , Jun Du  4 , De-Wei Dai  5
Affiliations

Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors

Chuan-Yu Wang et al. World J Gastrointest Oncol. .

Abstract

Background: The incidence of gastric cancer remains high, and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide. Oral contrast-enhanced ultrasonography is a simple, non-invasive, and painless method for the diagnosis of gastric tumors.

Aim: To explore the diagnostic value of oral contrast-enhanced ultrasonography for the detection of gastric tumors.

Methods: The screening results based on oral contrast-enhanced ultrasonography and electronic gastroscopy were compared with those of the postoperative pathological examination.

Results: Among 42 patients with gastric tumors enrolled in the study, the diagnostic accordance rate was 95.2% for oral contrast-enhanced ultrasonography (n = 40) and 90.5% for electronic gastroscopy (n = 38) compared with postoperative pathological examination. The Kappa value of consistency test with pathological findings was 0.812 for oral contrast-enhanced ultrasonography and 0.718 for electronic gastroscopy, and there was no significant difference between them (P = 0.397). For the TNM staging of gastric tumors, the accuracy rate of oral contrast-enhanced ultrasonography was 81.9% for the overall T staging and 50%, 77.8%, 100%, and 100% for T1, T2, T3, and T4 staging, respectively. The sensitivity and specificity were both 100% for stages T3 and T4. The diagnostic accuracy rate of oral contrast-enhanced ultrasonography was 93.8%, 80%, 100%, and 100% for stages N0, N1-N3, M0, and M1, respectively.

Conclusion: The accordance rate of qualitative diagnosis by oral contrast-enhanced ultrasonography is comparable to that of gastroscopy, and it could be used as the preferred method for the early screening of gastric tumors.

Keywords: Controlled study; Diagnosis; Electronic gastroscopy; Gastric tumor; Oral contrast-enhanced ultrasonography; Pathological examination.

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Conflict of interest statement

Conflict-of-interest statement: There is no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Oral contrast-enhanced ultrasonography showed localized thickening of the gastric wall at the greater curvature that suggested a diagnosis of gastric cancer, which was proven by postoperative pathological examination.
Figure 2
Figure 2
In a solid mass at the lesser curvature originating from the muscularis propria, oral contrast-enhanced ultrasonography indicated gastric stromal tumor, which was proven by postoperative pathological examination. A: Oral contrast-enhanced ultrasonography; B: Endoscopy image; C: Pathological examination.
See this image and copyright information in PMC

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