Effect of indomethacin on the electrical conductance and electrochemical voltammetry of copper chloride in methanol, ethanol, and their binary mixture with water

Abstract

This study investigated the physicochemical properties of the interaction of indomethacin and copper chloride using the electrical conductance measurement in methanol, ethanol, and their binary mixture with water at room temperature (298.15 K), to determine the solvation behavior, redox behavior, and kinetics. The association parameters were computed using the Fuoss-Hsia-Fernández-Prini and Fuoss-Shedlovsky models. The standard Gibbs energy for association (ΔG^o_A), Walden product (Λ_oη_o), and hydrodynamic radii (R_H) were calculated to study the interaction of indomethacin and copper chloride. On the other hand, cyclic voltammetry examines the electrochemical redox behavior of copper chloride using a gold electrode and its interactions with indomethacin. Results showed changes in peak potentials and currents density in the presence of indomethacin, indicating alterations in redox behavior and reaction rates. Overall, this research can be valuable in understanding the electrochemical properties and potential applications of indomethacin and copper chloride, as well as in developing new drugs or therapeutic agents, which could have has implications in various fields, including drug development, electrochemistry, and materials science.

Keywords: Association parameters; Copper chloride; Cyclic voltammetry and conductance models; Electrical conductance; Indomethacin.

Fig. 1

Chemical structure of Indomethacin.

Fig. 2

Molar conductivities (Ʌ_m) of CuCl₂ vs. the square of the concentration (C^1/2) in binary mixtures (MeOH–H₂O) in the absence of indomethacin at room temperature.

Fig. 3

Molar conductivities (Ʌ_m) of CuCl₂ vs. the square of the concentration (C^1/2) in the binary mixture (EtOH–H₂O) in the absence of indomethacin at room temperature.

Fig. 4

Cyclic voltammogram of CuCl₂ at different concentrations.

Fig. 5

Cyclic voltammograms for the interaction of (3.84 × 10⁻⁶) mol·cm⁻³ CuCl₂ with various indomethacin concentrations at scan rates of 0.1 V s^-1 and 298.15 K.

Fig. 6

Cyclic voltammogram of (3.636 × 10⁻⁶) mol·cm⁻³ CuCl₂ with (3.955 × 10⁻⁷) mol·cm⁻³ indomethacin at different scan rates and 298.15 K.

Fig. 7

Relationship between (ΔG) Gibbs free energy and (Log β_j) stability constant for (■) reduction peak and (●) oxidation peak at 298.15 K & a scan rate of 0.1 V s^-1.