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. 2024 Mar;41(3):693-702.
doi: 10.1007/s10815-024-03039-3. Epub 2024 Jan 31.

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles

Tamar Alkon-Meadows  1 , Carlos Hernandez-Nieto  2 , Tia Jackson-Bey  2   3 , Teresa A Cacchione  2 , Joseph Lee  2 , Martha Luna-Rojas  2 , Dmitry Gounko  2 , Alan Copperman  2   3 , Erkan Buyuk  2   3
Affiliations

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles

Tamar Alkon-Meadows et al. J Assist Reprod Genet. 2024 Mar.

Abstract

Purpose: To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.

Methods: This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.

Results: Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having a higher euploidy rate (aOR 1.31; 95% CI 0.63-2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.

Conclusions: Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET.

Keywords: Euploidy; In vitro fertilization; Live birth rate; Preimplantation genetic testing; Self-reported racial background.

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Conflict of interest statement

Dr. AC is an advisor and/or board member of Progyny. The remaining authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart showing the distribution of women who completed an IVF+PGT cycle
See this image and copyright information in PMC

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