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. 1979 Jan;130 A(1):23-7.

Loss of plasmid-mediated resistance after conversion of a group B streptococcus strain to a stable cell wall deficient variant

J Schmitt-Slomska, R Caravano, N El-Solh
  • PMID: 382949

Loss of plasmid-mediated resistance after conversion of a group B streptococcus strain to a stable cell wall deficient variant

J Schmitt-Slomska et al. Ann Microbiol (Paris). 1979 Jan.

Abstract

A group B streptococcus strain carrying plasmid DNA determining resistance to several drugs was converted by penicillin to cell wall (CW) defective and then to CW deficient variants (L-forms). The stable CW deficient variants became susceptible to antibiotics in study. Dye-buoyant density analysis of the DNA of CW deficient variants showed that the loss of antibiotic resistance was associated with the loss of extrachromosomal DNA.

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