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Review
. 2024 Apr 1;24(2):102-108.
doi: 10.1097/ACI.0000000000000971. Epub 2024 Jan 30.

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

Matteo Maule  1   2 , Joana Vitte  3   4 , Francesca Ambrosani  2 , Marco Caminati  1   2
Affiliations
Review

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

Matteo Maule et al. Curr Opin Allergy Clin Immunol. .

Abstract

Purpose of review: Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients.

Recent findings: In the last years, great efforts have been made by researchers worldwide to provide reliable epidemiological data on fungal sensitization and ABPA, especially in severe asthma patients both in adult and pediatric population. Data differ depending on the geographical area and population studied, but pooled data show a concerning 11% of severe asthma patients having ABPA and one out of four asthmatic patients being sensitized to fungi, Aspergillus fumigatus in particular.

Summary: Reliable epidemiological data and advances in the diagnostic procedures can facilitate the detection of ABPA among asthmatic patients, improving the management of a still under-recognized and challenging condition.

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References

    1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2023.
    1. Vitte J, Michel M, Malinovschi A, et al. EAACI Task Force on Allergic Bronchopulmonary Aspergillosis. Fungal exposome, human health, and unmet needs: a 2022 update with special focus on allergy. Allergy 2022; 77:3199–3216.
    1. Maule M, Olivieri B, Guarnieri G, et al. Hidden comorbidities in asthma: a perspective for a personalized approach. J Clin Med 2023; 12:2294.
    1. Agarwal R, Muthu V, Sehgal IS, et al. Prevalence of aspergillus sensitization and allergic bronchopulmonary aspergillosis in adults with bronchial asthma: a systematic review of global data. J Allergy Clin Immunol Pract 2023; 11:1734.e3–1751.e3.
    1. Hammad H, Lambrecht BN. The basic immunology of asthma. Cell 2021; 184:1469–1485.

MeSH terms