The Swedish National Facility for Magnetoencephalography Parkinson's disease dataset

Abstract

Parkinson's disease (PD) is characterised by a loss of dopamine and dopaminergic cells. The consequences hereof are widespread network disturbances in brain function. It is an ongoing topic of investigation how the disease-related changes in brain function manifest in PD relate to clinical symptoms. We present The Swedish National Facility for Magnetoencephalography Parkinson's Disease Dataset (NatMEG-PD) as an Open Science contribution to identify the functional neural signatures of Parkinson's disease and contribute to diagnosis and treatment. The dataset contains whole-head magnetoencephalographic (MEG) recordings from 66 well-characterised PD patients on their regular dose of dopamine replacement therapy and 68 age- and sex-matched healthy controls. NatMEG-PD contains three-minute eyes-closed resting-state MEG, MEG during an active movement task, and MEG during passive movements. The data includes anonymised MRI for source analysis and clinical scores. MEG data is rich in nature and can be used to explore numerous functional features. By sharing these data, we hope other researchers will contribute to advancing our understanding of the relationship between brain activity and disease state or symptoms.

Fig. 1

Overview of the MEG tasks. Top: three minutes resting state with the eyes closed. Middle: go task; participants had to respond when a visual cue changed colour after a random delay of 2.5-4.5 s. Bottom: passive movements; a device would induce passive movements after a random delay of 2.5-3.5 s. The visual stimuli during the passive movements were matched to the go task.

Fig. 2

Directory and file structure of NatMEG-PD. Only the folders for the first participant are shown (sub-001); the structure is identical for all other participants.

Fig. 3

(A) The spectral power of the entire raw resting-state data for all participants. Each line is the PSD for a single participant colour coded by group (orange for patients, light blue for healthy control). The thick lines are group means (red for patients, dark blue for healthy controls). The topography of the group averaged power is shown below for the frequency bands 8-10 Hz (alpha), 15-20 Hz (low beta), 30-40 Hz (low gamma), and 50 Hz (line noise frequency). (B) Summary of the average head movement during the resting state recording per participant split between groups.