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. 2024 Jan 31;19(1):100.
doi: 10.1186/s13018-024-04587-1.

Analysis of the natural collapse course of non-traumatic osteonecrosis of the femoral head based on the matrix model

Rushun Zhao #  1   2 , Mengfei Wang #  1   2 , Yangquan Hao  1 , Peng Xu  1 , Chao Lu  3
Affiliations

Analysis of the natural collapse course of non-traumatic osteonecrosis of the femoral head based on the matrix model

Rushun Zhao et al. J Orthop Surg Res. .

Abstract

Background: There are many predictions about the progression of natural collapse course of osteonecrosis of the femoral head. Here, we aimed to combine the three classical prediction methods to explore the progression of the natural collapse course.

Methods: This retrospective study included 127 patients admitted to our hospital from October 2016 to October 2017, in whom the femoral head had not collapsed. Logistic regression analysis was performed to determine the collapse risk factors, and Kaplan-Meier survival curves were used for femoral head survival analysis. The collapse rate of the femoral head was recorded within 5 years based on the matrix model. The specificity of the matrix model was analyzed using the receiver operating characteristic curve.

Results: A total of 127 patients with a total of 202 hips were included in this study, and 98 hips collapsed during the follow-up period. Multivariate logistics regression analysis showed that the predictive ability of the matrix model was stronger than Association Research Circulation Osseous staging, Japanese Investigation Committee classification, and area (P < 0.05). Kaplan-Meier survival curve showed that the median survival time of femoral head in patients was 3 years. The result of the receiver operating characteristic curve analysis showed that the area under the curve (AUC) of the matrix model had better predictive value (AUC = 0.771, log-rank test: P < 0.001).

Conclusion: We creatively combined the three classical prediction methods for evaluating the progression of the natural collapse course based on the matrix model and found that the higher the score of the matrix model, the higher the femoral head collapse rate. Specifically, the matrix model has a potential value in predicting femoral head collapse and guiding treatment selection.

Keywords: Collapse; Femoral head; Matrix model; Prediction; Risk factors.

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Conflict of interest statement

The authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan–Meier survival curve of the matrix model
Fig. 2
Fig. 2
ROC curve analysis of the matrix model. ROC, receiver operating characteristic
See this image and copyright information in PMC

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References

    1. Mont MA, Salem HS, Piuzzi NS, Goodman SB, Jones LC. Nontraumatic osteonecrosis of the femoral head: where do we stand today? A 5-year update. J Bone Joint Surg Am. 2020;102(12):1084–1099. doi: 10.2106/JBJS.19.01271. - DOI - PMC - PubMed
    1. Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun. 2020;110:102460. doi: 10.1016/j.jaut.2020.102460. - DOI - PubMed
    1. Liu J, Han X, Qu L, Du B. Identification of key ferroptosis-related biomarkers in steroid-induced osteonecrosis of the femoral head based on machine learning. J Orthop Surg Res. 2023;18(1):327. doi: 10.1186/s13018-023-03800-x. - DOI - PMC - PubMed
    1. Zhao DW, Yu M, Hu K, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey. Chin Med J (Engl) 2015;128(21):2843–2850. doi: 10.4103/0366-6999.168017. - DOI - PMC - PubMed
    1. Cui Q, Jo WL, Koo KH, et al. ARCO consensus on the pathogenesis of non-traumatic osteonecrosis of the femoral head. J Korean Med Sci. 2021;36(10):e65. doi: 10.3346/jkms.2021.36.e65. - DOI - PMC - PubMed

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