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. 2024 Jan 31;23(1):34.
doi: 10.1186/s12944-024-02020-4.

Association of hysterectomy with nonalcoholic fatty liver disease among US women

Shuanghong Jin  1 , Shaoxun Li  1 , Peipei Fang  1 , Chenwei Pan  1 , Shanshan Huang  2
Affiliations

Association of hysterectomy with nonalcoholic fatty liver disease among US women

Shuanghong Jin et al. Lipids Health Dis. .

Abstract

Background: A postmenopausal rise in the rates of nonalcoholic fatty liver disease (NAFLD) has been reported in women. This study thus sought to further probe the association of hysterectomy with NAFLD.

Methods: The data utilized in this investigation were attained from the 2017-March 2020 cycle of the National Health and Nutrition Examination Survey (NHANES), reflecting a strategic utilization of comprehensive health and nutrition information in the US population, to conduct a cross-sectional examination of the relationship between self-reported hysterectomy and NAFLD. Subjects included in this study were women aged 20 years or older. The multivariable logistic regression methodologies were utilized to determine the pertinent odds ratios (ORs) and their associated 95% confidence intervals (CIs).

Results: Of the 2,868 subjects enrolled in this study (mean age: 51.3 years, 95%CI: 50.0-52.6 years), 22.1% (95%CI: 19.7-24.7%) reported having undergone a hysterectomy, while 31.1% (95%CI: 28.1-34.1%) exhibited elastographic evidence of NAFLD, and 3.8% (95%CI: 2.6-5.6%) exhibited clinically significant fibrosis (CSF). Relative to women with no history of hysterectomy, those that had undergone hysterectomy exhibited a higher odd of NAFLD (OR:1.66, 95%CI: 1.24-2.21) in a multivariable model fully adjusted for age, ethnicity, body mass index, female hormone use, oophorectomy, diabetes, hyperlipidemia, and smoking status. Subgroup analyses revealed a stronger association among women who were not obese (OR:2.23, 95%CI:1.61-3.11), women who were not affected by diabetes (OR:1.76, 95%CI: 1.25-2.46), and without hyperlipidemia (OR: 1.87, 95%CI: 1.10-3.16). No significant association of hysterectomy with NAFLD encompassing CSF was identified.

Conclusions: The results of the present nationally representative analysis suggested an association between hysterectomy and increased NAFLD prevalence among US women. Knowledge of this relationship may better aid clinical efforts to screen for and manage NAFLD.

Keywords: Hysterectomy; Menopause; Nonalcoholic fatty liver disease; Women.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart for the selection and enrollment of study participants Abbreviations: NHANES, National Health and Nutrition Examination Survey
Fig. 2
Fig. 2
Association of hysterectomy with NAFLD in participant subgroups ORs and 95%CIs were derived from logistic regression models stratified for the indicated factors following adjustment for age, race and ethnicity, bilateral oophorectomy, female hormone use, BMI, diabetes, hyperlipidemia, and smoking status (with the exception of the factor used for stratification) Abbreviations: OR, odds ratio; CI: confidence interval; NAFLD: nonalcoholic fatty liver disease; BMI: body mass index
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