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. 2023 Oct 24:12:1401.
doi: 10.12688/f1000research.141399.1. eCollection 2023.

Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact

Stefan Jungbluth  1 , William Martin  1 , Monika Slezak  1 , Hilde Depraetere  1 , Carlos A Guzman  2 , Anton Ussi  3 , David Morrow  3 , Fran Van Heuverswyn  4 , Sven Arnouts  5 , Manuel J T Carrondo  6 , Ole Olesen  1 , Tom H M Ottenhoff  7 , H M Dockrell  8 , Mei Mei Ho  9 , Alexandre Dobly  10 , Dennis Christensen  11 , Joaquim Segalés  12 , Fabrice Laurent  13 , Frédéric Lantier  13 , Norbert Stockhofe-Zurwieden  14 , Francesca Morelli  15 , Jan A M Langermans  16 , Frank A W Verreck  16 , Roger Le Grand  17 , Arjen Sloots  18 , Donata Medaglini  19 , Maria Lawrenz  20 , Nicolas Collin  20
Affiliations

Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact

Stefan Jungbluth et al. F1000Res. .

Abstract

Background: Research infrastructures are facilities or resources that have proven fundamental for supporting scientific research and innovation. However, they are also known to be very expensive in their establishment, operation and maintenance. As by far the biggest share of these costs is always borne by public funders, there is a strong interest and indeed a necessity to develop alternative business models for such infrastructures that allow them to function in a more sustainable manner that is less dependent on public financing.

Methods: In this article, we describe a feasibility study we have undertaken to develop a potentially sustainable business model for a vaccine research and development (R&D) infrastructure. The model we have developed integrates two different types of business models that would provide the infrastructure with two different types of revenue streams which would facilitate its establishment and would be a measure of risk reduction. For the business model we are proposing, we have undertaken an ex ante impact assessment that estimates the expected impact for a vaccine R&D infrastructure based on the proposed models along three different dimensions: health, society and economy.

Results: Our impact assessment demonstrates that such a vaccine R&D infrastructure could achieve a very significant socio-economic impact, and so its establishment is therefore considered worthwhile pursuing.

Conclusions: The business model we have developed, the impact assessment and the overall process we have followed might also be of interest to other research infrastructure initiatives in the biomedical field.

Keywords: Vaccines; business model; impact assessment; research and development; research infrastructure; science policy; sustainability.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Overview of the functioning of the contract development partnership model within the vaccine RI based on the hybrid business model.
Blue arrows indicate financial flows, grey arrows scientific-technical or other types of participation and contribution.
Figure 2.
Figure 2.. Monetisation model for the contract development partnership.
Figure 3.
Figure 3.. Overview of the functioning of the bio-holding model within the vaccine RI based on the hybrid business model.
Blue arrows indicate financial flows, grey arrows scientific-technical or other types of participation and contribution.
Figure 4.
Figure 4.. Monetisation model for the bio-holding.
Figure 5.
Figure 5.. Socio-economic impact of the vaccine RI.
The ex ante socio-economic impact of the vaccine RI with the proposed hybrid business model was assessed along the three dimensions indicated.
See this image and copyright information in PMC

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