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Review
. 2025;17(1):102-112.
doi: 10.2174/0125899775280160240122065607.

Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Prabhat Kumar Upadhyay  1 , Navneet Thakur  2 , Vishal Kumar Vishwakarma  2 , Hridaya Shankar Chaurasiya  3 , Tarique Mahmood Ansari  4
Affiliations
Review

Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Prabhat Kumar Upadhyay et al. Curr Drug Res Rev. 2025.

Abstract

The angiotensin-converting enzyme-2 (ACE-2) alters the pathophysiology of various fatal cardiovascular diseases, including ischemic heart disease, whereas angiotensin 1-7 (Ang 1-7) exerts a wide range of actions. The effects of ischemia-reperfusion (IR) injury include damage to myocardial tissue that initiates protease action, causing cardiac cell death. Angiotensin- II (Ang-II) contributes through the renin-angiotensin system (RAS) to the IR injury, whereas Ang 1-7 paradoxically exerts a protective effect through the same. Thus, the myocardial ischemic reperfusion injury (MIRI) may be altered by the RAS of the heart. This review paper focuses on ACE-2, angiotensin-converting enzyme (ACE), and Ang 1-7 regulation in the RAS of the heart in the pathophysiology of MIRI. The treatment in such conditions using ACE-2 activator, ACE inhibitor, and Ang-II antagonists may promote vascular functions as well as cardio- protection.

Keywords: ACE inhibitor; ACE-2 activator; Heart; angiotensin-II antagonist.; myocardial ischemia-reperfusion injury; renin-angiotensin system.

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