Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 1;134(3):e176253.
doi: 10.1172/JCI176253.

Clinical investigation of hypoxia-inducible factors: getting there

Gregg L Semenza

Clinical investigation of hypoxia-inducible factors: getting there

Gregg L Semenza. J Clin Invest. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: GLS is an inventor on provisional patent application US/63,231,216 and is a founder of, and holds equity in, HIF Therapeutics Inc. This arrangement has been reviewed and approved by Johns Hopkins University in accordance with its conflict-of-interest policies.

References

    1. Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest. 2013;123(9):3664–3671. doi: 10.1172/JCI67230. - DOI - PMC - PubMed
    1. Yu AY, et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J Clin Invest. 1999;103(5):691–696. doi: 10.1172/JCI5912. - DOI - PMC - PubMed
    1. Rankin EB, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117(4):1068–1077. doi: 10.1172/JCI30117. - DOI - PMC - PubMed
    1. Hickey MM, et al. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest. 2010;120(3):827–839. doi: 10.1172/JCI36362. - DOI - PMC - PubMed
    1. Brusselmans K, et al. Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest. 2003;111(10):1519–1527. doi: 10.1172/JCI15496. - DOI - PMC - PubMed

MeSH terms

Substances