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Editorial
. 2024 Apr 15;209(8):899-900.
doi: 10.1164/rccm.202312-2259ED.

Novel Role of the GSDMB/IFNG Axis in Childhood Asthma

Affiliations
Editorial

Novel Role of the GSDMB/IFNG Axis in Childhood Asthma

Anthony Bosco. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.
    Jakwerth CA, Weckmann M, Illi S, Charles H, Zissler UM, Oelsner M, Guerth F, Omony J, Nemani SSP, Grychtol R, Dittrich AM, Skevaki C, Foth S, Weber S, Alejandre Alcazar MA, van Koningsbruggen-Rietschel S, Brock R, Blau S, Hansen G, Bahmer T, Rabe KF, Brinkmann F, Kopp MV, Chaker AM, Schaub B, von Mutius E, Schmidt-Weber CB; ALLIANCE Study Group as part of the German Center for Lung Research. Jakwerth CA, et al. Am J Respir Crit Care Med. 2024 Apr 15;209(8):947-959. doi: 10.1164/rccm.202305-0934OC. Am J Respir Crit Care Med. 2024. PMID: 38064241 Free PMC article.

References

    1. Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med . 2013;368:1398–1407. - PMC - PubMed
    1. Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, et al. New insights relating gasdermin B to the onset of childhood asthma. Am J Respir Cell Mol Biol . 2022;67:430–437. - PMC - PubMed
    1. Ono JG, Kim BI, Zhao Y, Christos PJ, Tesfaigzi Y, Worgall TS, et al. Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes. J Clin Invest . 2020;130:921–926. - PMC - PubMed
    1. Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, III, Stanhope C, et al. Environmental Influences on Child Health Outcomes-Children’s Respiratory Research Workgroup Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med . 2020;8:482–492. - PMC - PubMed
    1. Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science . 2020;368:eaaz7548. - PubMed