Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 11;16(1):137-145.
doi: 10.14336/AD.2024.0109. Online ahead of print.

Fighting with Aging: The Secret for Keeping Health and Longevity of Naked Mole Rats

Wenjing Yang  1 , Yifan Hu  2   3 , Shufang Cui  1
Affiliations
Review

Fighting with Aging: The Secret for Keeping Health and Longevity of Naked Mole Rats

Wenjing Yang et al. Aging Dis. .

Abstract

Health and longevity are the dreams of mankind and the main field of the medical community. The naked mole rat (NMR) is a unique murine animal with extremely long lives (exceeding 38 years), revealing little signs of aging such as reproductive decline, neural degenerative diseases, and cancer. They provide us with valuable perspectives on preventing age-related diseases. This review systematically summarized the characters of different systems of naked mole rats in aging resistance, and furtherly exploited the mechanisms for aging resistance form genome, telomeres, protein recycling, metabolism, and oxidative stress attitudes. As a species with a high similarity with human beings, it cannot be ruled out that after reasonable validity, safety and ethical evaluation, the dominant genes of naked mole rats will be developed in medical transformation, to realize the dream of human health and longevity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts in this manuscript.

Figures

Figure 1.
Figure 1.
Characters and mechanisms of aging resistance in naked mole rats. Various organisms of naked mole rats show aging resistance. The underlying mechanisms may be due to gene evolutions, maintenance of genome stability, telomeres, ros, and protein recycling mechanisms.
See this image and copyright information in PMC

References

    1. Crimmins EM (2015). Lifespan and Healthspan: Past, Present, and Promise. Gerontologist, 55:901-911. - PMC - PubMed
    1. Niccoli T, Partridge L (2012). Ageing as a risk factor for disease. Curr Biol, 22:R741-752. - PubMed
    1. Jagger C, Gillies C, Moscone F, Cambois E, Van Oyen H, Nusselder W, et al.. (2008). Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis. Lancet, 372:2124-2131. - PubMed
    1. Stenholm S, Head J, Aalto V, Kivimäki M, Kawachi I, Zins M, et al.. (2017). Body mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study. Int J Obes (Lond), 41:769-775. - PMC - PubMed
    1. Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, et al.. (2018). Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature, 563:131-136. - PubMed