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Editorial
. 2024 Feb 2;134(3):325-327.
doi: 10.1161/CIRCRESAHA.124.324212. Epub 2024 Feb 1.

Aging Two-Step: SOX9's Influence on Vascular Stiffness and Senescence

Parya Behzadi  1 , Cynthia St Hilaire  1   2
Affiliations
Editorial

Aging Two-Step: SOX9's Influence on Vascular Stiffness and Senescence

Parya Behzadi et al. Circ Res. .
No abstract available

Keywords: Editorials; aged; animals; humans; osteogenesis.

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Conflict of interest statement

Disclosures None.

Figures

None
Senescence and stiffness are sufficient to induce expression of SOX9 in SMCs (1) which promotes the elevation of extracellular matrix-modifying proteins such as LH3 and proteins necessary for endosomal and extracellular vesicle (EVs) formation (2). In these cells LH3 is packaged into EVs and delivered to the extracellular space (3), where its collagen modification functions further promotes stiffness (4) which feeds forward promoting senescence in neighboring cells.
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References

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