Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May 1;26(5):248-251.
doi: 10.34172/aim.2023.38.

Incidence of Retinopathy of Prematurity in Neonates with Neonatal Sepsis

Hassan Boskabadi  1 , Majid Abrishami  2 , Nasser Shoeibi  2 , Mahsa Kakavandi  3 , Maryam Moradi  4 , Maryam Zakerihamidi  5
Affiliations

Incidence of Retinopathy of Prematurity in Neonates with Neonatal Sepsis

Hassan Boskabadi et al. Arch Iran Med. .

Abstract

Background: One of the most important complications of premature birth is retinopathy of prematurity (ROP). Sepsis may increase the incidence of this complication. The aim of this study is to compare the incidence of ROP in neonates with and without sepsis.

Methods: In a retrospective case-control study, preterm infants admitted to the neonatal intensive care unit (NICU) of Ghaem hospital from 2014 to 2022 were examined. The case group consisted of 155 preterm infants with definite sepsis (positive blood culture and clinical signs of sepsis) and the control group included 145 preterm infants without sepsis whose maternal and neonatal characteristics were collected; they were examined by a retinologist and evaluated for ROP at 32 weeks or four weeks after birth. Finally, we used the chi-square and the t test to compare the two groups.

Results: Out of 155 preterm infants with sepsis, 70% and out of 145 preterm infants without sepsis, 58% had ROP (P=0.023). Also, low birth weight, low initial Apgar score and low 5-minute Apgar score were significantly associated with ROP (P<0.05).

Conclusion: Based on the results of this study, sepsis is a serious risk factor for ROP. We can reduce its incidence and complication by preventing sepsis in premature infants.

Keywords: Gestational age; Infants; Neonatal sepsis; Preterm; Retinopathy of prematurity.

PubMed Disclaimer

Conflict of interest statement

Competing Interests

None.

Figures

Figure 1
Figure 1
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Boskabadi H, Bagheri F, Askari Hosseni Z. Developmental disorders in preterm neonates during the first two years of life using the ages and stages questionnaire. J Babol Univ Med Sci. 2016;18(2):7–13. doi: 10.22088/jbums.18.2.7. - DOI
    1. Abrishami M, Maemori GA, Boskabadi H, Yaeghobi Z, Mafi-Nejad S, Abrishami M. Incidence and risk factors of retinopathy of prematurity in Mashhad, northeast Iran. Iran Red Crescent Med J. 2013;15(3):229–33. doi: 10.5812/ircmj.4513. - DOI - PMC - PubMed
    1. Saugstad OD. Oxygen and retinopathy of prematurity. J Perinatol. 2006;26 Suppl 1:S46–50. doi: 10.1038/sj.jp.7211475. - DOI - PubMed
    1. Chiang MF, Arons RR, Flynn JT, Starren JB. Incidence of retinopathy of prematurity from 1996 to 2000: analysis of a comprehensive New York state patient database. Ophthalmology. 2004;111(7):1317–25. doi: 10.1016/j.ophtha.2003.10.030. - DOI - PubMed
    1. Liu J, Wang Q, Zhao JH, Chen YH, Qin GL. The combined antenatal corticosteroids and vitamin K therapy for preventing periventricular-intraventricular hemorrhage in premature newborns less than 35 weeks gestation. J Trop Pediatr. 2006;52(5):355–9. doi: 10.1093/tropej/fml028. - DOI - PubMed