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. 2024 Feb;45(2):81-84.
doi: 10.1016/j.it.2024.01.003. Epub 2024 Jan 31.

SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences

Xinling Wang  1 , Lu Lu  1 , Shibo Jiang  2
Affiliations

SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences

Xinling Wang et al. Trends Immunol. 2024 Feb.

Abstract

SARS-CoV-2 is continuously evolving. The Omicron subvariant BA.2.86, with >30 mutations in its spike (S) protein compared with its predecessor strain BA.2, was expected to quickly become predominant worldwide, but this has not happened. Instead, its descendant strain, JN.1, with just one additional mutation, has become the predominant SARS-CoV-2 subvariant. Here, we offer a possible explanation for these unexpected consequences.

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Conflict of interest statement

Declaration of interests We declare no competing interests.

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