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Review
. 2024;24(13):1488-1505.
doi: 10.2174/0118715303265274231204075802.

A Review on Role of Inflammation in Coronavirus Disease

Arezoo Lotfi  1 , Pouran Hajian  2 , Laleh Abbasi  3 , Morad Kohandel Gargari  4 , Najmeh Nameh Goshay Fard  5 , Delaram Naderi  6
Affiliations
Review

A Review on Role of Inflammation in Coronavirus Disease

Arezoo Lotfi et al. Endocr Metab Immune Disord Drug Targets. 2024.

Abstract

The respiratory illness known as COVID-19 is caused by the novel coronavirus, SARS-CoV-2. While the precise pathogenic mechanism of COVID-19 remains unclear, the occurrence of a cytokine storm subsequent to viral infection plays a pivotal role in the initiation and advancement of the disease. The infection of SARS-CoV-2 induces a state of immune system hyperactivity, leading to an excessive production of inflammatory cytokines. Consequently, the identification of the various signaling pathways implicated in the inflammation induced by COVID-19 will enable researchers to investigate new targets for therapeutic intervention.

Keywords: COVID-19; SARS-CoV-2.; coronavirus disease; cytokine storm; immune response; inflammation.

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