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Review
. 2024 Jan 18:11:1287714.
doi: 10.3389/fbioe.2023.1287714. eCollection 2023.

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Tingyu Wang  1   2 , Yanxing Zhou  3 , Wenwen Zhang  1 , Yuanye Xue  1 , Ziteng Xiao  1 , Yanfang Zhou  1   2 , Xinsheng Peng  4   5
Affiliations
Review

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Tingyu Wang et al. Front Bioeng Biotechnol. .

Abstract

Promoting complete periodontal regeneration of damaged periodontal tissues, including dental cementum, periodontal ligament, and alveolar bone, is one of the challenges in the treatment of periodontitis. Therefore, it is urgent to explore new treatment strategies for periodontitis. Exosomes generated from stem cells are now a promising alternative to stem cell therapy, with therapeutic results comparable to those of their blast cells. It has great potential in regulating immune function, inflammation, microbiota, and tissue regeneration and has shown good effects in periodontal tissue regeneration. In addition, periodontal tissue engineering combines exosomes with biomaterial scaffolds to maximize the therapeutic advantages of exosomes. Therefore, this article reviews the progress, challenges, and prospects of exosome and exosome-loaded composite scaffolds in periodontal regeneration.

Keywords: biomaterial scaffolds; exosomes; periodontal regeneration; stem cells; tissue engineering.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Biogenesis process and main components of exosomes. Figures created with BioRender.com with an academic license.
FIGURE 2
FIGURE 2
Strategy of exosome combined with biomaterial scaffold in the treatment of periodontitis. Figures created with BioRender.com with an academic license.
See this image and copyright information in PMC

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