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Review
. 2024 Jan 18:10:1325002.
doi: 10.3389/fmolb.2023.1325002. eCollection 2023.

SIRT1 and thrombosis

Alessandra Bettiol #  1 , Maria Letizia Urban #  1 , Giacomo Emmi  1 , Silvia Galora  2 , Flavia Rita Argento  2 , Eleonora Fini  2 , Serena Borghi  2 , Giacomo Bagni  1 , Irene Mattioli  1 , Domenico Prisco  1 , Claudia Fiorillo #  2 , Matteo Becatti #  2
Affiliations
Review

SIRT1 and thrombosis

Alessandra Bettiol et al. Front Mol Biosci. .

Abstract

Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and coagulation. Furthermore, SIRT1 displays anti-inflammatory activity both in vitro, in vivo and in clinical studies, particularly via the reduction of oxidative stress. On these bases, several studies have investigated the therapeutic potential of targeting SIRT1 for the prevention of thrombosis. This review provides a comprehensive and critical overview of the main preclinical and clinical studies and of the current understanding of the role of SIRT1 in thrombosis.

Keywords: SIRT1; atherosclerosis; oxidative stress; sirtuins; thrombosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer ML declared a shared affiliation with the authors at the time of review. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

FIGURE 1
FIGURE 1
The role of SIRT1 in thrombotic pathways. ABCA1: ATP Binding Cassette Subfamily A Member 1; ABCG1: ATP binding cassette subfamily G member 1; CCR7: chemokine (C-C motif) receptor 7; CRIF1: CR6-interacting factor 1; eNOS: endothelial nitric oxide synthase; ICAM: intercellular adhesion molecule; LXR: liver X receptors; NF-κb: nuclear factor κb; NO: nitric oxide; Ox-LDL: oxidized low-density lipoprotein; PAFR: platelet-activating factor receptor; PPAR-γ: Peroxisome proliferator-activated receptor gamma; STEMI: ST elevation myocardial infarction; TIMP3: tissue metalloproteinase 3; TLR4: Toll-like receptor 4; VCAM: vascular cell adhesion molecule; vWF: von Willebrand factor.
See this image and copyright information in PMC

References

    1. Akhmedov A., Camici G. G., Reiner M. F., Bonetti N. R., Costantino S., Holy E. W., et al. (2017). Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways. Cardiovasc Res. 113 (5), 498–507. 10.1093/cvr/cvx015 - DOI - PubMed
    1. Alqarni M. H., Foudah A. I., Muharram M. M., Labrou N. E. (2021). The pleiotropic function of human sirtuins as modulators of metabolic pathways and viral infections. Cells 10 (2), 460. 10.3390/cells10020460 - DOI - PMC - PubMed
    1. Alves-Fernandes D. K., Jasiulionis M. G. (2019). The role of SIRT1 on DNA damage response and epigenetic alterations in cancer. Int. J. Mol. Sci. 20 (13), 3153. 10.3390/ijms20133153 - DOI - PMC - PubMed
    1. Anrather J., Racchumi G., Iadecola C. (2006). NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J. Biol. Chem. 281 (9), 5657–5667. 10.1074/jbc.M506172200 - DOI - PubMed
    1. Aquila G., Vieceli Dalla Sega F., Marracino L., Pavasini R., Cardelli L. S., Piredda A., et al. (2020). Ticagrelor increases SIRT1 and HES1 mRNA levels in peripheral blood cells from patients with stable coronary artery disease and chronic obstructive pulmonary disease. Int. J. Mol. Sci. 21 (5), 1576. 10.3390/ijms21051576 - DOI - PMC - PubMed