Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 16;6(2):100965.
doi: 10.1016/j.jhepr.2023.100965. eCollection 2024 Feb.

Transplant oncology - Current indications and strategies to advance the field

Felix J Krendl  1 , Ruben Bellotti  1 , Gonzalo Sapisochin  2 , Benedikt Schaefer  3 , Herbert Tilg  3 , Stefan Scheidl  1 , Christian Margreiter  1 , Stefan Schneeberger  1 , Rupert Oberhuber  1 , Manuel Maglione  1
Affiliations
Review

Transplant oncology - Current indications and strategies to advance the field

Felix J Krendl et al. JHEP Rep. .

Erratum in

Abstract

Liver transplantation (LT) was originally described by Starzl as a promising strategy to treat primary malignancies of the liver. Confronted with high recurrence rates, indications drifted towards non-oncologic liver diseases with LT finally evolving from a high-risk surgery to an almost routine surgical procedure. Continuously improving outcomes following LT and evolving oncological treatment strategies have driven renewed interest in transplant oncology. This is not only reflected by constant refinements to the criteria for LT in patients with HCC, but especially by efforts to expand indications to other primary and secondary liver malignancies. With new patient-centred oncological treatments on the rise and new technologies to expand the donor pool, the field has the chance to come full circle. In this review, we focus on the concept of transplant oncology, current indications, as well as technical and ethical aspects in the context of donor organs as precious resources.

Keywords: CCA; CRLM; HCC; HEHE; Liver transplantation; NELM; hepatoblastoma; transplant oncology.

PubMed Disclaimer

Conflict of interest statement

The authors of this study declare that they do not have any conflict of interest. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
Factors fuelling the renewed interest in the field of transplant oncology.
Fig. 2
Fig. 2
Combining technical innovations such as machine perfusion with innovative surgical concepts such as RAPID has the potential to further bridge the gap between organ supply and demand.
Fig. 3
Fig. 3
Summary of current and potential future concepts of transplant oncology.
See this image and copyright information in PMC

References

    1. Iwatsuki S., Klintmalm G.B., Starzl T.E. Total hepatectomy and liver replacement (orthotopic liver transplantation) for primary hepatic malignancy. World J Surg. 1982;6:81–85. doi: 10.1007/bf01656377. - DOI - PMC - PubMed
    1. Sapisochin G., Hibi T., Ghobrial M., et al. The ILTS consensus conference on transplant oncology: setting the stage. Transplantation. 2020;104:1119–1120. doi: 10.1097/tp.0000000000003175. - DOI - PubMed
    1. Lai Q., Levi Sandri G.B., Lerut J. Selection tool alpha-fetoprotein for patients waiting for liver transplantation: how to easily manage a fractal algorithm. World J Hepatol. 2015;7:1899–1904. doi: 10.4254/wjh.v7.i15.1899. - DOI - PMC - PubMed
    1. Mehta N., Bhangui P., Yao F.Y., et al. Liver transplantation for hepatocellular carcinoma. Working group report from the ILTS transplant oncology consensus conference. Transplantation. 2020;104:1136–1142. doi: 10.1097/tp.0000000000003174. - DOI - PubMed
    1. Hibi T., Rela M., Eason J.D., et al. Liver transplantation for colorectal and neuroendocrine liver metastases and hepatoblastoma. Working group report from the ILTS transplant oncology consensus conference. Transplantation. 2020;104:1131–1135. doi: 10.1097/tp.0000000000003118. - DOI - PubMed

LinkOut - more resources