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Review
. 2024 Jan 18:17:11364.
doi: 10.3389/or.2023.11364. eCollection 2023.

Metastatic Pancreatic Cancer: Where Are We?

Abraham Hernández-Blanquisett  1   2 , Valeria Quintero-Carreño  1   3 , María Cristina Martínez-Ávila  1 , María Porto  1 , María Carolina Manzur-Barbur  1   4 , Emiro Buendía  1   4
Affiliations
Review

Metastatic Pancreatic Cancer: Where Are We?

Abraham Hernández-Blanquisett et al. Oncol Rev. .

Abstract

Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which generally leads to late diagnosis, at which point there is no option for curative surgery. The treatment of metastatic pancreatic cancer includes systemic therapy, in some cases radiotherapy, and more recently, molecular targeted therapies, which can positively impact cancer control and improve quality of life. This review provides an overview of the molecular landscape of pancreatic cancer based on the most recent literature, as well as current treatment options for patients with metastatic pancreatic cancer.

Keywords: chemotherapy; metastatic pancreatic cancer; molecular targeted therapy; pancreatic cancer; supportive care.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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