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. 2024 Feb 2;19(2):e0298444.
doi: 10.1371/journal.pone.0298444. eCollection 2024.

Expression of Concern: Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies

PLOS ONE Editors

Expression of Concern: Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies

PLOS ONE Editors. PLoS One. .
No abstract available

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Figures

Fig 5
Fig 5. Influence of minocycline on p-STAT3, p-ERK1/2 and Mcl-1 expression in ovarian cancer cells.
SKOV-3 cells were treated with minocycline (100 μM) with or without IL-1β (10 ng/ml) stimulation for different time points. The expression levels of (A) p-STAT3, STAT3; (B) Mcl-1 or (C) p-ERK1/2, ERK1/2 were estimated by western blot analysis. Densitometric analysis is expressed as mean ± SD intensity of optical density obtained by three independent experiments (*p<0.05, **p<0.01 and ***p<0.001 vs. control cells, #p<0.05, ##p<0.01 vs. IL-1β treated cells).
See this image and copyright information in PMC

Expression of concern for

References

    1. Ataie-Kachoie P, Morris DL, Pourgholami MH (2013) Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies. PLoS ONE 8(4): e60817. doi: 10.1371/journal.pone.0060817 - DOI - PMC - PubMed
    1. Parvin Ataie-Kachoie, Samina Badar, Morris David L., Mohammad H. Pourgholami; Minocycline Targets the NF-κB Nexus through Suppression of TGF-β1-TAK1-IκB Signaling in Ovarian Cancer. Mol Cancer Res 1 October 2013; 11 (10): 1279–1291. 10.1158/1541-7786.MCR-13-0239 - DOI - PubMed

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