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. 1985 Oct-Dec;10(4):279-88.
doi: 10.1007/BF03189755.

Pharmacokinetics of theophylline and its metabolites in rabbits

A Celardo, G L Traina, A Jankowski, M Bonati

Pharmacokinetics of theophylline and its metabolites in rabbits

A Celardo et al. Eur J Drug Metab Pharmacokinet. 1985 Oct-Dec.

Abstract

The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

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References

    1. Pediatr Res. 1981 Apr;15(4 Pt 1):304-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 May;78(5):3260-4 - PubMed
    1. Toxicol Lett. 1980 Nov;7(1):1-7 - PubMed
    1. J Pharmacokinet Biopharm. 1978 Apr;6(2):135-51 - PubMed
    1. Br J Pharmacol Chemother. 1967 Feb;29(2):136-49 - PubMed