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Review
. 2025;32(17):3423-3437.
doi: 10.2174/0109298673279032231214110313.

Multifaceted Nature of HuR in Atherosclerosis Development

Yan-Xia Wang  1 , Hong-Yu Zheng  1 , Kun Zhou  1 , Hai-Lin Xie  1 , Zhong Ren  1 , Hui-Ting Liu  1 , Huan Liu  1 , Zhi-Xiang Zhou  1 , Zhi-Sheng Jiang  1
Affiliations
Review

Multifaceted Nature of HuR in Atherosclerosis Development

Yan-Xia Wang et al. Curr Med Chem. 2025.

Abstract

HuR (Human antigen R) is an RNA binding protein (RBP) that specifically binds to certain RNA sequences, influencing post-transcriptional regulation. HuR is primarily involved in tumor regulation, as well as cell growth, proliferation, inflammation, and angiogenesis. HuR is implicated in endothelial activation, smooth muscle proliferation, inflammatory response, macrophage apoptosis, lipid regulation, and autophagy, playing a crucial regulatory role in atherosclerosis. Accumulating evidence suggests that HuR has dual roles in AS. On the one hand, HuR expedites the development of AS by facilitating endothelial activation, smooth muscle proliferation, and inflammation. On the contrary, it exerts beneficial effects by reducing macrophage apoptosis, regulating lipid efflux, and increasing autophagy. In this review, we aim to provide a comprehensive summary of the role of HuR in the development of AS by examining its involvement in cellular mechanisms, inflammation, autophagy, and apoptosis. Additionally, we discuss the mechanisms of drugs that target HuR, with the goal of offering new perspectives for the treatment of AS.

Keywords: 3‘ UTR; Atherosclerosis; embryonic lethal.; endothelial cells; human antigen R; nucleoplasmic translocation.

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