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Editorial
. 2024 Feb 5;5(1):5.
doi: 10.1186/s43556-023-00168-6.

Unlocking γδ T cell power: pathways that boost cancer defense

Yuhao Yao #  1 , Zhi Zong #  2 , Long Zhang  3   4   5
Affiliations
Editorial

Unlocking γδ T cell power: pathways that boost cancer defense

Yuhao Yao et al. Mol Biomed. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Model of regulation of the butyrophilin complex. Activation of the BTN2A1-3A1-3A2 complex through phosphoantigen metabolite engagement with BTN3A1 intracellular binding pocket. Genetic perturbations and inhibitors affecting metabolic pathways, specifically those involved in ATP production, were discovered to modulate BTN3A levels. This induction of BTN3A and BTN2A1 occurs during metabolic crises and relies on AMPK, ultimately enhancing Vγ9Vδ2 T cell receptor-mediated killing. endoplasmic reticulum (ER), endoplasmic reticulum; oxidative phosphorylation (OXPHOS), oxidative phosphorylation
See this image and copyright information in PMC

Comment on

  • CRISPR screens decode cancer cell pathways that trigger γδ T cell detection.
    Mamedov MR, Vedova S, Freimer JW, Sahu AD, Ramesh A, Arce MM, Meringa AD, Ota M, Chen PA, Hanspers K, Nguyen VQ, Takeshima KA, Rios AC, Pritchard JK, Kuball J, Sebestyen Z, Adams EJ, Marson A. Mamedov MR, et al. Nature. 2023 Sep;621(7977):188-195. doi: 10.1038/s41586-023-06482-x. Epub 2023 Aug 30. Nature. 2023. PMID: 37648854 Free PMC article.

References

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