Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School

Luisa B Binder¹, Priscila B Rosa², Bárbara M de Sousa³, Luana S Chagas⁴, Olga Dubljević⁵, Fanny Sandrine Martineau⁶, Francesca Mottarlini⁷, Sílvia Castany², Lorena Morton⁸, Fran Krstanović⁹, Isadora D Tassinari¹⁰, Jeiny L Choconta¹¹, Ana Raquel Pereira-Santos¹², Laetitia Weinhard¹³, Praveen N Pallegar¹⁴, Björn F Vahsen^{15

16}, Izabela Lepiarz-Raba¹⁷, Anne-Claire Compagnion⁶, Marina Lorente-Picón¹⁸

Affiliations

¹ Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Quebec City, Canada.
² Center for Social and Affective Neuroscience (CSAN), Linköping University, Linköping, Sweden.
³ Institute of Biomedicine (iBiMED), Department of Medical Sciences, Universidade de Aveiro, Aveiro, Portugal.
⁴ Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, Brazil.
⁵ Department of Neurobiology, Univerzitet u Beogradu Institut za Biološka Istraživanja Siniša Stanković, Institute for Biological Research, Beograd, Republic of Serbia.
⁶ Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
⁷ Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.
⁸ Faculty of Medicine, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University, Magdeburg, Germany.
⁹ Faculty of Medicine, Center for Proteomics, University of Rijeka, Rijeka, Croatia.
¹⁰ Department of Physiology, Graduate Program in Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
¹¹ Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
¹² Center for Neuroscience and Cell Biology (CNC), CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
¹³ NYU Grossman School of Medicine, New York, New York, USA.
¹⁴ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁵ Nuffield Department of Clinical Neurosciences, Oxford Motor Neuron Disease Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK.
¹⁶ Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
¹⁷ BRAINCITY: Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
¹⁸ Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

PMID: 38311960
DOI: 10.1111/ejn.16262

Free article

Editorial

Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School

Luisa B Binder et al. Eur J Neurosci. 2024 Apr.

Free article

. 2024 Apr;59(8):1977-1992.

doi: 10.1111/ejn.16262. Epub 2024 Feb 4.

Authors

Affiliations

¹ Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Quebec City, Canada.
² Center for Social and Affective Neuroscience (CSAN), Linköping University, Linköping, Sweden.
³ Institute of Biomedicine (iBiMED), Department of Medical Sciences, Universidade de Aveiro, Aveiro, Portugal.
⁴ Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, Brazil.
⁵ Department of Neurobiology, Univerzitet u Beogradu Institut za Biološka Istraživanja Siniša Stanković, Institute for Biological Research, Beograd, Republic of Serbia.
⁶ Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
⁷ Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.
⁸ Faculty of Medicine, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University, Magdeburg, Germany.
⁹ Faculty of Medicine, Center for Proteomics, University of Rijeka, Rijeka, Croatia.
¹⁰ Department of Physiology, Graduate Program in Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
¹¹ Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
¹² Center for Neuroscience and Cell Biology (CNC), CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
¹³ NYU Grossman School of Medicine, New York, New York, USA.
¹⁴ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁵ Nuffield Department of Clinical Neurosciences, Oxford Motor Neuron Disease Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK.
¹⁶ Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
¹⁷ BRAINCITY: Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
¹⁸ Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

PMID: 38311960
DOI: 10.1111/ejn.16262

Abstract

In a great partnership, the Federation of European Neuroscience Societies (FENS) and the Hertie Foundation organized the FENS-Hertie 2022 Winter School on 'Neuro-immune interactions in health and disease'. The school selected 27 PhD students and 13 postdoctoral fellows from 20 countries and involved 14 faculty members experts in the field. The Winter School focused on a rising field of research, the interactions between the nervous and both innate and adaptive immune systems under pathological and physiological conditions. A fine-tuned neuro-immune crosstalk is fundamental for healthy development, while disrupted neuro-immune communication might play a role in neurodegeneration, neuroinflammation and aging. However, much is yet to be understood about the underlying mechanisms of these neuro-immune interactions in the healthy brain and under pathological scenarios. In addition to new findings in this emerging field, novel methodologies and animal models were presented to foment research on neuro-immunology. The FENS-Hertie 2022 Winter School provided an insightful knowledge exchange between students and faculty focusing on the latest discoveries in the biology of neuro-immune interactions while fostering great academic and professional opportunities for early-career neuroscientists from around the world.

Keywords: microglia; neurodevelopment and neurodegeneration; neuro‐immune interactions.

PubMed Disclaimer

References

REFERENCES

1. Albertini, G., D'Andrea, I., Druart, M., Béchade, C., Nieves‐Rivera, N., Etienne, F., Le Magueresse, C., Rebsam, A., Heck, N., Maroteaux, L., & Roumier, A. (2023). Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills. Molecular Psychiatry, 28, 2328–2342. https://doi.org/10.1038/s41380-023-02048-5
1. Albertini, G., Etienne, F., & Roumier, A. (2020). Regulation of microglia by neuromodulators: Modulations in major and minor modes. Neuroscience Letters, 733, 135000. https://doi.org/10.1016/j.neulet.2020.135000
1. Beccari, S., Sierra‐Torre, V., Valero, J., Pereira‐Iglesias, M., García‐Zaballa, M., Soria, F. N., De Las Heras‐Garcia, L., Carretero‐Guillen, A., Capetillo‐Zarate, E., Domercq, M., Huguet, P. R., Ramonet, D., Osman, A., Han, W., Dominguez, C., Faust, T. E., Touzani, O., Pampliega, O., Boya, P., … Sierra, A. (2023). Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy. Autophagy, 19(7), 1952–1981. https://doi.org/10.1080/15548627.2023.2165313
1. Béchade, C., D'Andrea, I., Etienne, F., Verdonk, F., Moutkine, I., Banas, S. M., Kolodziejczak, M., Diaz, S. L., Parkhurst, C. N., Gan, W. B., Maroteaux, L., & Roumier, A. (2021). The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood. Glia, 69(3), 638–654. https://doi.org/10.1002/glia.23918
1. Bellocchi, A. (2022). Science students' social bonds and knowledge construction. Journal of Research in Science Teaching., 59(5), 746–778. https://doi.org/10.1002/tea.21743

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School

Affiliations

Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources