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. 1979 Jul;40(1):72-80.
doi: 10.1038/bjc.1979.142.

Marrow autotransplantation accelerates haematological recovery in patients with malignant melanoma treated with high-dose melphalan

T J McElwain, D W Hedley, G Burton, H M Clink, M Y Gordon, M Jarman, C A Juttner, J L Millar, R A Milsted, G Prentice, I E Smith, D Spence, M Woods
Free PMC article

Marrow autotransplantation accelerates haematological recovery in patients with malignant melanoma treated with high-dose melphalan

T J McElwain et al. Br J Cancer. 1979 Jul.
Free PMC article

Abstract

In a Phase I study, melphalan 140 mg/m2 was administered to 8 patients with disseminated malignant melanoma. Marrow was removed from the patients immediately before melphalan administration and returned i.v. 8 h later. Studies on marrow culture and melphalan pharmacokinetics predicted that this was a safe time to administer non-cryopreserved marrow. Four patients received lower doses of i.v. melphalan without autologous marrow. In the group receiving autologous marrow the time for recovery of peripheral-blood granulocytes to 800/mm2 or greater was significantly less (P = 0.01) than in those not receiving marrow. In 7 patients the tumour showed evidence of response to the drug and there was 1 complete remission. This treatment deserves investigation in patients with tumours more sensitive to drugs than melanoma.

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