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. 2023 Nov 14;79(Pt 12):1147-1150.
doi: 10.1107/S205698902300974X. eCollection 2023 Dec 1.

Synthesis and crystallographic characterization of 6-hydroxy-1,2-dihydropyridin-2-one

Sara K Phillips  1 , Savannah G Brancato  1 , Samantha N MacMillan  2 , Mark J Snider  3 , Andrew J Roering  1 , Katherine A Hicks  1
Affiliations

Synthesis and crystallographic characterization of 6-hydroxy-1,2-dihydropyridin-2-one

Sara K Phillips et al. Acta Crystallogr E Crystallogr Commun. .

Abstract

The title compound, C5H5NO2, is a hy-droxy-lated pyridine ring that has been studied for its involvement in microbial degradation of nicotinic acid. Here we describe its synthesis as a formic acid salt, rather than the standard hydro-chloride salt that is commercially available, and its spectroscopic and crystallographic characterization.

Keywords: crystal structure; hydrogen bonding; nicotinic acid derivative.

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Figures

Figure 1
Figure 1
A view of 2 showing the atom-numbering scheme for one independent mol­ecule. Displacement ellipsoids are drawn at the 50% probability level.
Figure 2
Figure 2
A view of the inter­molecular inter­actions in 2.
Figure 3
Figure 3
A view of the mol­ecular packing in 2.
Figure 4
Figure 4
(a) Hirshfeld surface representations of 2 with the function d norm plotted onto the surface indicating the E—H⋯O (E = N, O) inter­actions; (b) two-dimensional fingerprint plot.
See this image and copyright information in PMC

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