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. 2023 Oct;16(10):1448-1451.
doi: 10.25122/jml-2023-0027.

Variations of blood viscosity in acute typhoid fever: A cross-sectional study

Salah Al-Windy  1
Affiliations

Variations of blood viscosity in acute typhoid fever: A cross-sectional study

Salah Al-Windy. J Med Life. 2023 Oct.

Abstract

Typhoid fever (TF) is a systemic infection caused by Salmonella Typhi (Salmonella Enterica) transmitted through contaminated water, food, or contact with infected individuals. In various infectious diseases, blood viscosity (BV) is affected by changes in hemoglobin concentrations and acute phase reactants. Inflammatory responses can lead to elevated plasma protein levels and further affect BV. This study aimed to investigate BV changes in patients with acute TF. A cross-sectional study was performed involving 55 patients with acute TF compared to 38 healthy controls. BV and inflammatory parameters were measured in both groups. TF patients showed reduced blood cells compared to healthy controls (p=0.001). Additionally, plasma total protein (TP) levels significantly increased to 10.79±1.05 g/L in TF patients compared to 7.035±1.44 g/L in healthy controls (p=0.03). Hematocrit (HCT) levels were 11.67±2.89% in TF patients and 12.84±2.02% in healthy controls (p=0.07), suggesting a trend towards increased BV in TF patients. Elevated BV is involved in the pathogenesis of different inflammatory and infectious diseases. The increased BV in TF patients may raise the risk of complications. Therefore, monitoring BV might be a crucial tool in TF patients, mainly in the high-risk group, for early detection of cardiovascular complications.

Keywords: blood viscosity; cardiovascular complications; typhoid fever.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
White blood cell levels in patients with typhoid fever compared to controls
Figure 2
Figure 2
Total protein levels in patients with typhoid fever compared to controls
Figure 3
Figure 3
Hematocrit level in patients with typhoid fever compared to the controls
Figure 4
Figure 4
High shear blood viscosity in patients with typhoidfever compared to controls
Figure 5
Figure 5
Low shear blood viscosity in patients with typhoid fever compared to caontrols
See this image and copyright information in PMC

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