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. 2024 Jan 19:15:1301921.
doi: 10.3389/fendo.2024.1301921. eCollection 2024.

Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China

Chen Yang #  1   2 , Shaohua Li #  3 , Liangyan Wu #  4 , Zan Ding  5 , Hua Zhou  6 , Ying Pan  1 , Chufu Yang  7 , Jinjun Lin  1 , Qiang Li  8 , Yingbin You  6 , Xu Zhong  1 , Yuyuan Chen  1 , Yu Zhao  1
Affiliations

Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China

Chen Yang et al. Front Endocrinol (Lausanne). .

Abstract

Background: Prediabetes is associated with an increased risk of cardiovascular diseases and all-cause mortality. Rare research in China has evaluated the prevalence of prediabetes among children and adolescents using the HbA1c criterion or the combined FPG-or-HbA1c diagnostic criterion, and researchers paid no attention to the distributions of blood glucose in Shenzhen, especially for juveniles.

Methods: We conducted a school-based cross-sectional study based on the first-year students from 17 primary, middle, and high schools. Prediabetes was defined as FPG of 5.6-6.9 mmol/L or HbA1c of 5.7%-6.4%. The crude and standardized prevalence of prediabetes with 95% confidence interval (95% CI) was estimated.

Results: A total of 7519 participants, aged 6 to 17 years, were included. For all subjects, the crude prevalence (95% CI) of prediabetes was 1.49% (1.21-1.77), 8.72% (8.08-9.36), and 9.80% (9.13-10.47) by the FPG-only, HbA1c-only, and FPG-or-HbA1c criteria, respectively. Based on the 2010 Shenzhen census population, the standardized prevalence was 1.56% (males 1.85%, females 1.19%), 11.05% (males 11.47%, females 10.53%), and 12.19% (males 13.01%, females 11.15%) by the corresponding criteria. The proportion of prediabetes was higher for males than females, and the prevalence decreased with grade for males but increased for females. The association of BMI and prediabetes was U-shaped curve, indicating higher rates of prediabetes for underweight and obesity people.

Conclusion: The blood glucose status of children and adolescents in Shenzhen is worrisome, and the early detection and management of prediabetes are imperative.

Keywords: Shenzhen; adolescents; children; prediabetes; prevalence.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Scatter charts and Spearman correlation analyses of FPG with HbA1c values among the children and adolescents of Shenzhen by sex and grade.
Figure 2
Figure 2
Crude sex-prevalence of prediabetes by grade among the children and adolescents of Shenzhen, China in 2017, according to FPG-only (A), HbA1c-only (B), and the combined FPG-or-HbA1c (C) diagnostic criteria.
Figure 3
Figure 3
Crude grade-prevalence of prediabetes by sex among the children and adolescents of Shenzhen, China in 2017, according to FPG-only (A), HbA1c-only (B), and the combined FPG-or-HbA1c (C) diagnostic criteria.
Figure 4
Figure 4
Standardized prevalence of prediabetes among the children and adolescents of Shenzhen, China in 2017 by the FPG-only, HbA1c-only, and FPG-or-HbA1c criteria, based on the 2010 Shenzhen Census Population (A) and 2010 Chinese National Census Population (B).
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