doi: 10.1016/0889-1605(85)90130-2.
Type-A retrovirus particles in heterohybridomas: precaution for human monoclonal antibody purification
- PMID: 3831387
- DOI: 10.1016/0889-1605(85)90130-2
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Type-A retrovirus particles in heterohybridomas: precaution for human monoclonal antibody purification
J Ultrastruct Res.
1985 Jul-Aug.
Abstract
Fine structural features of the murine myeloma MHFP-1 and two heterohybridomas secreting human IgM monoclonal antibody were examined. Intracisternal type-A retrovirus particles were found in both MHFP-1 and the heterohydribomas constructed by fusing MHFP-1 and human peripheral blood lymphocytes. The implications of this finding for the purification of human monoclonal antibody for therapeutic applications is discussed.
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