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. 2023 Jul-Sep;49(3):381-387.
doi: 10.12865/CHSJ.49.03.10. Epub 2023 Sep 30.

Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life

Andrei Biţă  1   2 , Ion Romulus Scorei  1 , Tudor Adrian Bălşeanu  1   3 , Gabriela Rău  1   4 , Maria Viorica Ciocîlteu  1   5 , George Dan Mogoşanu  1   2
Affiliations

Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life

Andrei Biţă et al. Curr Health Sci J. 2023 Jul-Sep.

Abstract

The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high intestinal absorption rate, inducing alpha2-macroglobulin (A2M) expression for longevity and healthy life. ZBC is metabolized by hydrolysis, mainly at the absorption site (intestinal level), and most of it is excreted in the urine. Within seven hours from the administration in mice, almost the entire amount of orally absorbed ZBC is eliminated in a metabolized form. The highest amount of A2M protein in mouse liver was determined by immunoabsorbance assay in the chronic experiment (1000mg/kg of ZBC), followed by the subchronic experiment (at the same dose of ZBC), and by the acute experiment (5000mg/kg of ZBC).

Keywords: A2M protein; dietary supplement; healthy life; longevity; zinc-boron complex.

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Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Absorption-elimination curve for ZBC administered p.o., in a dose of 250mg/kg, in mice. p.o.: Per os; ZBC: Zinc-boron complex
Figure 2
Figure 2
Determination of A2M protein levels (expressed relative to GAPDH) in mouse liver, after p.o. administration of five different doses of ZBC, in an acute experiment (n=5; mean±standard deviation, Student’s t-test). A2M: α2-Macroglobulin; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; p.o.: Per os; ZBC: Zinc-boron complex
Figure 3
Figure 3
Determination of A2M protein levels (expressed relative to GAPDH) in mouse liver, after p.o. administration of three different doses of ZBC, in a subchronic experiment (n=5; mean±standard deviation, Student’s t-test). A2M: α2-Macroglobulin; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; p.o.: Per os; ZBC: Zinc-boron complex.
Figure 4
Figure 4
Determination of A2M protein levels (expressed relative to GAPDH) in mouse liver, after p.o. administration of three different doses of ZBC, in a chronic experiment (n=5; mean±standard deviation, Student’s t-test). A2M: α2-Macroglobulin; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; p.o.: Per os; ZBC: Zinc-boron complex
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