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Review
. 2024 Dec;19(6):293-299.
doi: 10.1007/s11899-024-00724-z. Epub 2024 Feb 5.

Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders

Kelly M Pennington  1 , Douglas Simonetto  2 , Timucin Taner  3 , Abhishek A Mangaonkar  4
Affiliations
Review

Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders

Kelly M Pennington et al. Curr Hematol Malig Rep. 2024 Dec.

Abstract

Purpose of the review: This study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with telomere biology disorders (TBD). Specifically, this review focuses on clinical management of lung, liver, and bone marrow transplantation in TBD patients.

Recent findings: TBD patients have specific unique biological vulnerabilities such as T cell immunodeficiency, susceptibility to infections, hypersensitivity to chemotherapy and radiation, and cytopenias. Furthermore, multiple organ involvement at diagnosis makes clinical management especially challenging due to higher degree of organ damage, and stress-induced telomeric crisis. Sequential and combined organ transplants, development of novel radiation and alkylator-free conditioning regimen, and use of novel drugs for graft-versus-host disease prophylaxis are some of the recent updates in the field. Multidisciplinary management is essential to optimize transplant outcomes in patients with TBD. In this review, we provide consensus-based transplant management guidelines for clinical management of transplant in TBD.

Keywords: Bone marrow transplant; Liver transplant; Lung transplant; TBD; Telomere biology disorders; Transplantation.

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Conflict of interest statement

Declarations Ethics Approval Not applicable. Competing Interests Authors disclose no relevant conflicts of interest in relation to the manuscript. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.

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