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Randomized Controlled Trial
. 2024 Feb 5;7(2):e2354719.
doi: 10.1001/jamanetworkopen.2023.54719.

Music as an Intervention to Improve the Hemodynamic Response of Ketamine in Depression: A Randomized Clinical Trial

Kyle T Greenway  1   2 , Nicolas Garel  1 , Lê-Anh L Dinh-Williams  1   2 , Serge Beaulieu  1   3 , Gustavo Turecki  1   3   4 , Soham Rej  1   2   5 , Stephane Richard-Devantoy  1   3   4
Affiliations
Randomized Controlled Trial

Music as an Intervention to Improve the Hemodynamic Response of Ketamine in Depression: A Randomized Clinical Trial

Kyle T Greenway et al. JAMA Netw Open. .
No abstract available

Plain language summary

This randomized clinical trial explores whether music improves the hemodynamic response of ketamine among patients with treatment-resistant depression in Canada.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Beaulieu reported grants from the Canadian Institutes of Health Research (peer-reviewed funding), grants from Otsuka-Lundbeck (investigator-initiated trial), personal fees from Abbvie (consultant and speaker), personal fees from Otsuka (consultant and speaker), personal fees from Janssen (consultant and speaker), personal fees from Sunovion (consultant and speaker), personal fees from Takeda (consultant), personal fees from Idorsia (consultant), and personal fees from Eisai (consultant) outside the submitted work. Dr Rej reported clinician-scientist salary award from Fonds de Recherche Sante Quebec, grants from Mitacs, shareholder of Aifred Health, and on a steering committee (postobservational marketing study) for AbbVie outside the submitted work. Dr Richard-Devantoy reported grants from Réseau québécois sur le suicide, les troubles de l’humeur et les troubles associés (RQSHA) during the conduct of the study. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Study Flow Diagram
MDE indicates major depressive episode; MUSIK, Music for Subanesthetic Infusions of Ketamine randomized clinical trial; SUD, substance use disorder.
Figure 2.
Figure 2.. Aggregate Group Changes in Blood Pressure
Figure shows aggregate group changes in blood pressure across 181 ketamine infusions: differences from baseline to 40 minutes for systolic and diastolic blood pressure calculated using generalized estimating equations (A), and the raw mean systolic blood pressure values over the course of the infusion (B). Error bars indicate 95% CIs.
See this image and copyright information in PMC

References

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