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Review
. 2024 Mar-Apr;26(3):105309.
doi: 10.1016/j.micinf.2024.105309. Epub 2024 Feb 4.

Gut microb-aging and its relevance to frailty aging

Guillaume Le Cosquer  1 , Nathalie Vergnolle  2 , Jean-Paul Motta  3
Affiliations
Free article
Review

Gut microb-aging and its relevance to frailty aging

Guillaume Le Cosquer et al. Microbes Infect. 2024 Mar-Apr.
Free article

Abstract

This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations in microbiota's taxonomy and metabolism, as well as with concepts of ecological resilience, pathobionts emergence, and biogeography. We examine microb-aging in interconnected body organs, emphasizing the bidirectional relationship with 'inflammaging'. Finally, we discuss how targeting microb-aging could improve screening, diagnostic, and therapeutic approaches in geriatrics.

Keywords: Aging and frailty; Geroprotector; Geroscience; Inflammaging; Microb-aging.

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Conflict of interest statement

Declaration of competing interest The authors declare no relevant conflict of interest.

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