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. 2024 Oct;30(7):4705-4720.
doi: 10.1111/odi.14890. Epub 2024 Feb 5.

Maternal periodontitis potentiates monosodium glutamate-obesity damage on Wistar offspring's fast-glycolytic muscle

Liziane Nunes Conrad Costa  1 , Thayná Petry de Paula  2 , Matheus Felipe Zazula  3 , Katya Naliwaiko  3 , Carlos Augusto Nassar  2 , Gladson Ricardo Flor Bertolini  4 , Marcia Miranda Torrejais  5 , Lucinéia de Fátima Chasko Ribeiro  1 , Rose Meire Costa  1
Affiliations

Maternal periodontitis potentiates monosodium glutamate-obesity damage on Wistar offspring's fast-glycolytic muscle

Liziane Nunes Conrad Costa et al. Oral Dis. 2024 Oct.

Abstract

Objective: To evaluate the effects of magnifying the damage caused by obesity induced by monosodium glutamate, using a model of maternal periodontitis, on the structure of the anterior tibialis muscle of the offspring.

Materials and methods: Twenty-four female Wistar rats were divided into four experimental groups: control (n = 6), obese (n = 6), control with periodontitis (n = 6) and obese with periodontitis (n = 6). At 78 days of life, the rats were mated with males without any experimental intervention. The offspring of these rats (n = 1/L), at 120 days of life, were weighed and measured, then euthanized. Plasma was collected for analysis of cytokines IL-6, IL-10, IL-17 and TNF-α. Adipose tissues were collected and weighed, and the anterior tibial muscle was designated for histomorphological analyses (n = 6/group).

Results: Monosodium glutamate offspring showed significant muscle changes, such as a reduction in the size of fibres and neuromuscular junctions, and an increase in the nucleus and capillaries. However, all these changes were more expressed in monosodium glutamate-obese with periodontitis offspring.

Conclusion: This leads us to suggest a magnifying effect promoted by periodontitis to the damage already well described by monosodium glutamate-obesity, determined by low-intensity inflammation, causing greater muscle damage.

Keywords: chronic inflammatory diseases; foetal programming; histological alterations; tibialis anterior.

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